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Goto PI

Project for Host-Microbial Interactions in Symbiosis and Pathogenesis

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Research interests

Innumerable microorganisms peacefully colonize human mucosal tissues, including the gut. In particular, many bacteria, fungi, viruses, and parasites residing in the gut exert various effects on the host, such as inducing the differentiation and proliferation of immune cells. It is an attractable biological theme to identify the mechanism of symbiosis between the host and these intestinal microbes. In addition, it has been reported that disruption of the host and microbe symbiotic relationship predisposes the development of various diseases such as infectious diseases, inflammatory bowel disease, allergic diseases, metabolic disorders such as obesity and diabetes, and colon cancer. In contrast to symbiotic responses, host immune cells immediately eliminate pathogenic microbes from the gut. How this "symbiosis" with intestinal microbes and "exclusion" of pathogenic microbes is established is unclear yet. Commensal bacteria residing in the gut play important roles in 1. inhibition of colonization and infection by pathogenic microorganisms in the gut, and 2. induction of the host immune system. Our laboratory discovered that commensal bacteria and the host immune system interact cooperatively to form a first-line defense barrier against pathogen infection. Currently, we conduct daily research with the following research themes through elucidation of the mechanism of "symbiosis" with commensal bacteria and the "elimination" of pathogenic microorganisms.

  1. Identify commensal bacteria and their metabolites that inhibit colonization and infection of pathogenic microorganisms in the gut. Establish novel commensal bacteria-based treatment strategies against infectious diseases.
  2. Elucidate the mechanisms of differentiation and function of pathogenic or homeostatic Th17 cells and group 3 innate lymphoid cells that are controlled by intestinal bacteria and fungi.
  3. Establish mouse model infected by non-model pathogenic microbes through strategically controlling intestinal flora. Elucidate the mechanism of infection and host immune system.
  4. Establish strategies for optimizing vaccine efficacy using commensal bacteria and their metabolites. Develop commensal based-natural vaccine strategies.
  5. lab

    Staffs

    Yoshiyuki Goto Associate Professor
    Sawako Domae Research Promotion Technician
    Kaori Nishiyabu Research Promotion Technician

    Selected Publications

    1. Kamioka M, Goto Y, et al. Proc Natl Acad Sci U S A.119: e2115230119, 2022
    2. Goto Y. Cell Host Microbe. 30: 3-5, 2022
    3. Nagao-Kitamoto H, et al. Nat Med. 26: 608-617, 2020
    4. Fujimoto K, et al. Gastroenterology. 157: 1530-1543.e4, 2019
    5. Ichikawa T, et al. Nat Immunol. 20: 1469-1480, 2019
    6. Goto Y. Front Immunol. 10: 2057, 2019
    7. Matsuo K, et al. Microbiol Immunol. 63:155-163, 2019
    8. Goto Y, et al. Nat Immunol, 17: 1244-1251, 2016.
    9. Goto Y, et al. Scientific Reports, 5: 15918, 2015.
    10. Goto Y, et al. Science, 345: 1254009, 2014.
    11. Goto Y, et al. Immunity, 40: 594-607, 2014.
    12. Goto Y, Kiyono H. Immunol Rev ; 245: 147-163, 2012.

    Website

    http://www.pf.chiba-u.ac.jp/project_symbiosis/