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Yoneyama PI

Project for Immune Responses in Infectious Diseases

lab lab

Research interests

Recognition of pathogen-associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs) triggers innate immune responses, which lead to swift eradication of the infected pathogens. Furthermore, PRR-mediated signaling is critical for activation and regulation of the subsequent adaptive immunity. Thus, we focus on molecular machinery and physiological significance of PRR-mediated signaling in anti-viral and anti-fungal immune responses.

Viral infection is detected by RIG-I-like receptors (RLRs), which recognize viral non-self RNA as PAMPs, and activate expression of anti-viral cytokines, such as type I interferons (IFNs). Among three RLR family members, RIG-I and MDA5 detect 5’-triphsphate containing short double-stranded RNA (dsRNA) and long dsRNA, respectively. We try to understand molecular mechanism(s) underlying recognition of these substrates by RLRs using molecular biological, cell biological and biochemical approaches. We are also interested in how fungal infection is detected by PRRs, such as C-type lectin-like receptors (CLRs).

lab

Staffs

YONEYAMA, Mitsutoshi Professor
ONOMOTO, Koji Assistant Professor
ONOGUCHI, Kazuhide Assistant Professor
AOKI, Yuna Technical Official
TAKIZAWA, Miyuki Research Promotion Technician

Selected Publications

  1. Onomoto K. et al., Cell. Mol. Immunol., 18:539-555, 2021.
  2. Takahashi T. et al., Nucleic Acids Res., 48, 1494-1507, 2020.
  3. Takahasi K. et al., Biochem. Biophys. Res. Commun., 517, 662-669, 2019.
  4. Takahashi T. et al., Nucleic Acids Res., 46, 9134-9147, 2018.
  5. Yoneyama, M. et al., Curr. Opin. Immunol., 32, 48-53, 2015.
  6. Onomoto, K. et al., Trends Immunol., 35, 420-428, 2014.
  7. Yoo, JS. et al., PLoS Pathog., 10, e1004012, 2014.
  8. Onomoto, K. et al., PLoS One, 7, e43031, 2012.
  9. Onoguchi, K. et al., PLoS Pathg., 6, e1001012, 2010.
  10. Yoneyama, M. & Fujita, T., Rev. Med. Immunol., 20, 4-22, 2010.
  11. Takahasi, K. et al., Mol. Cell, 29, 428-440, 2008.
  12. Kato, H. et al., Nature, 441, 101-105, 2006.
  13. Kato, H. et al., Immunity, 23, 19-28, 2005.
  14. Yoneyama, M. et al., J. Immunol., 175 2851-2858, 2005.
  15. Yoneyama, M. et al., Nat. Immunol., 5, 730-737, 2004.

Website

http://www.pf.chiba-u.ac.jp/project_immuneresponses/

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