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Yasunori Muraosa

Position Assistant Professor
Research Projects Project to Link Basic Sciences and Clinical Medicine
Division Division of Clinical Research
TEL +81 43 226 2785
FAX +81 43 226 2486
E-mail muraosa[at]


Veterinary mycology, Medical mycology, Molecular biology

Main topics of research

  1. Development of new diagnostic methods for mycosis using real-time PCR.
  2. Functional analysis of Aspergillus fumigatus virulence factors.
  3. Molecular epidemiology of human fusariosis.
  4. Research of mycosis in marine organisms.

Main publications

  1. Hino Y, Muraosa Y, Oguchi M, Yahiro M, Yarita K, Watanabe A, Sakaida E, Yokote K, Kamei K: Drain outlets in patient rooms as sources for invasive fusariosis: an analysis of patients with haematological disorders. J Hosp Infect, S0195-6701(20)30204-8, 2020.
  2. Hoshino A, Tokoro S, Akashi T, Inoue M, Takagi M, Imai K, Kanegane H, Muraosa Y, Kamei K, Morio T: Disseminated fusariosis in a child after haploidentical hematopoietic stem cell transplantation. Pediatr Int, 62: 419-420, 2020.
  3. Nakamura A, Tawara I, Ino K, Matsumoto T, Hayashi A, Imai H, Muraosa Y, Kamei K, Katayama N: Achievement of long-term remission of disseminated histoplasmosis in an AIDS patient. Med Mycol Case Rep, 27: 25-28, 2020.
  4. Hanashiro J, Muraosa Y, Toyotome T, Hirose K, Watanabe A, Kamei K: Schizophyllum commune induces IL-17-mediated neutrophilic airway inflammation in OVA-induced asthma model mice. Sci Rep, 9(1):19321, 2019.
  5. Muraosa Y, Toyotome T, Yahiro M, Kamei K: Characterisation of novel-cell-wall LysM-domain proteins LdpA and LdpB from the human pathogenic fungus Aspergillus fumigatus. Sci Rep, 9(1):3345, 2019.
  6. Fujita Y, Ishiwada N, Takei H, Suwabe S, Yarita K, Ohkusu M, Muraosa Y, Kamei K, Shimojo N: Usefulness of Gastric Aspirate Culture for Diagnosing Congenital Immunodeficiency in an Infant with Fungal Pneumonia Caused by Rasamsonia piperina. Tohoku Journal of Experimental Medicine, 247, 265-269, 2019.
  7. Moretti ML, Busso-Lopes AF, Tararam CA, Moraes R, Muraosa Y, Mikami Y, Gonoi T, Taguchi H, Lyra L, Reichert-Lima F, Trabasso P, de Hoog GS, Al-Hatmi AMS, Schreiber AZ, Kamei K: Airborne transmission of invasive fusariosis in patients with hematologic malignancies. Plos One, 13(4):e0196426, 2018.
  8. Fujimoto M, Inaba Y, Takahashi T, Nakanishi G, Muraosa Y, Yahiro M, Kamei K, Murata S: Image Gallery: Granulomatous dermatitis due to infection with the chlorophyllic green alga Desmodesmus. British Journal of Dermatology, 179, E167-E167, 2018.
  9. Okada K, Endo T, Hashimoto D, Saga T, Ara T, Ogasawara R, Yasumoto A, Ibata M, Takahata M, Shigematsu A, Kondo T, Muraosa Y, Nomura T, Kanno-Okada H, Hashino S, Tanaka S, Kamei K, Teshima T: Disseminated fusariosis emerged from prolonged local genital infection after cord blood transplantation. J Infect Chemother, 24(8):660-663, 2018.
  10. Uemura S, Tamura A, Yamamoto N, Saito A, Nakamura S, Fujiwara T, Tahara T, Kozaki A, Kishimoto K, Ishida T, Hasegawa D, Muraosa Y, Kamei K, Kosaka Y: Successful Combination Therapy of Liposomal Amphotericin B and Caspofungin for Disseminated Fusariosis in a Pediatric Patient with Acute Lymphoblastic Leukemia. Pediatr Infect Dis J, 37(10):e251-e253, 2018.
  11. Muraosa Y, Oguchi M, Yahiro M, Watanabe A, Yaguchi T, Kamei K: Epidemiological study of Fusarium species causing invasive and superficial fusariosis in Japan. Med Mycol J, 58, E5-e13, 2017.
  12. de Souza M, Matsuzawa T, Sakai K, Muraosa Y, Lyra L, Busso-Lopes AF, Levin ASS, Schreiber AZ, Mikami Y, Gonoi T, Kamei K, Moretti ML, Trabasso P: Comparison of DNA Microarray, Loop-Mediated Isothermal Amplification (LAMP) and Real-Time PCR with DNA Sequencing for Identification of Fusarium spp. Obtained from Patients with Hematologic Malignancies. Mycopathologia, 182: 625-632, 2017.
  13. Hirayama T, Takazono T, Iwata K, Senju H, Shimazaki T, Tashiro M, Saijo T, Tanaka T, Nakamura S, Imamura Y, Kojiro M, Miyazaki T, Tsukamoto M, Furumoto A, Morimoto K, Muraosa Y, Matsubara Y, Yanagihara K, Mukae H, Kamei K, Kohno S, Izumikawa K: A case series of histoplasmosis patients with elevated serum soluble interleukin-2 receptor levels. J Infect Chemother 23: 642-647, 2017.
  14. Muraosa Y, Toyotome T, Yahiro M, Watanabe A, Shikanai-Yasuda MA, Kamei K: Detection of Histoplasma capsulatum from clinical specimens by cycling probe-based real-time PCR and nested real-time PCR. Med Mycol, 54(4): 433-8, 2016.
  15. Trabasso P, Matsuzawa T, Fagnani R, Muraosa Y, Tominaga K, Resende MR, Kamei K, Mikami Y, Schreiber AZ, Moretti ML: Isolation and Drug Susceptibility of Candida parapsilosis Sensu Lato and other Species of C-parapsilosis Complex from Patients with Blood Stream Infections and Proposal of a Novel LAMP Identification Method for the Species. Mycopathologia 179(1-2): 53-62, 2015.
  16. Takahashi-Nakaguchi A, Muraosa Y, Hagiwara D, Sakai K, Toyotome T, Watanabe A, Kawamoto S, Kamei K, Gonoi T, Takahashi H: Genome sequence comparison of Aspergillus fumigatus strains isolated from patients with pulmonary aspergilloma and chronic necrotizing pulmonary aspergillosis. Med Mycol 53(4): 353-360, 2015.
  17. Kawakami H, Inuzuka H, Hori N, Takahashi N, Ishida K, Mochizuki K, Ohkusu K, Muraosa Y, Watanabe A, Kamei K: Inhibitory effects of antimicrobial agents against Fusarium species. Med Mycol, 53(6): 603-11, 2015.
  18. Duc PM, Thy DTM, Hatai K, Muraosa Y: Infection of striped catfish (Pangasianodon hypophthalmus) in Viet Nam caused by the fungus Fusarium incarnatum-equiseti. Bulletin of the European Association of Fish Pathologists, 35: 208-216, 2015.
  19. Fagnani R, Resende MR, Trabasso P, Mikami Y, Schreiber AZ, Lopes AFB, Muraosa Y, Kamei K, Moretti ML: Mortality related to candidemia and risk factors associated with non-Candida albicans. Infectious Diseases, 47: 930-931, 2015.
  20. Wang DN, Toyotome T, Muraosa Y, Watanabe A, Wuren T, Bunsupa S, Aoyagi K, Yamazaki M, Takino M, Kamei K: GliA in Aspergillus fumigatus is required for its tolerance to gliotoxin and affects the amount of extracellular and intracellular gliotoxin. Med Mycol, 52(5): 506-518, 2014.
  21. Wuren T, Toyotome T, Yamaguchi M, Takahashi-Nakaguchi A, Muraosa Y, Yahiro M, Wang DN, Watanabe A, Taguchi H, Kamei K: Effect of Serum Components on Biofilm Formation by Aspergillus fumigatus and Other Aspergillus Species. Jpn J Infect Dis, 67(3): 172-179, 2014.
  22. Muraosa Y, Schreiber AZ, Trabasso P, Matsuzawa T, Taguchi H, Moretti ML, Mikami Y, Kamei K: Development of cycling probe-based real-time PCR system to detect Fusarium species and Fusarium solani species complex (FSSC). Int J Med Microbiol, 304(3-4): 505-511, 2014.
  23. Kikuchi K, Watanabe A, Ito J, Oku Y, Wuren T, Taguchi H, Yarita K, Muraosa Y, Yahiro M, Yaguchi T, Kamei K: Antifungal susceptibility of Aspergillus fumigatus clinical isolates collected from various areas in Japan. J Infect Chemother, 20(5): 336-338, 2014.
  24. Kanchan C, Muraosa Y, Hatai K: Exophiala angulospora infection found in cultured Japanese flounder Paralichthys olivaceus in Japan. Bulletin of the European Association of fish Pathologists, 34(5): 187-194, 2014.
  25. Ferrari MD, Resende MR, Sakai K, Muraosa Y, Lyra L, Gonoi T, Mikami Y, Tominaga K, Kamei K, Schreiber AZ, Trabasso P, Moretti ML:Visual analysis of DNA microarray data for accurate molecular identification of non-albicans Candida isolates from patients with candidemia episodes. J Clin Microbiol, 51(11): 3826-3829, 2013.
  26. Kamei K, Watanabe A, Yaguchi T, Muraosa Y, Toyotome T, Ohno H, Miyazaki Y: Epidemiology of imported mycoses in Japan - its past and the present status. Int J Antimicrob Agents, 42, S122-S122, 2013.
  27. Muraosa Y, Sano A, and Hatai K:Molecular Identification of Marine Crustacean-pathogenic Peronosporomycetes Using DNA Sequences of ITS1 and their Pathogenicity for Nauplii of Brine Shrimps. Fish Pathology, 47 (2), 41-48, 2012.
  28. Muraosa Y, Morimoto K, Sano A, Nishimura K and Hatai K:A new peronosporomycete, Halioticida noduliformans gen. et sp. nov., isolated from white nodules in the abalone Haliotis spp. from Japan. Mycoscience, 50 (2), 106-115, 2009.
  29. Atami H, Muraosa Y, and Hatai K:Halioticida Infection Found in Wild Mantis Shrimp Oratosquilla oratoria in Japan. Fish Pathology, 44 (3), 145-150, 2009.
  30. Muraosa Y, Lawhavinit O and Hatai K:Lagenidium thermophilum isolated from eggs and larvae of black tiger shrimp Penaeus monodon in Thailand. Fish Pathology, 41(1), 35-40, 2006.