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Kazuyoshi Kobayashi

Position Specially Appointed Assistant Professor
Research Projects Project for RNA regulation
Division Joint Division of RNA Therapy
TEL +81 43 226 2801
E-mail k-kobayashi[at]


Molecular Biology

Main topics of research

Development of NF-kappaB inhibitors

Main publications

  1. Kobayashi K*, Hiramatsu H*, Nakamura S, Kobayashi K, Haraguchi T, Iba, H. (* equally contrbuted) Tumor suppression via inhibition of SWI/SNF complex-dependent NF-κB activation. Scientific Reports, 7:11772 (2017)
  2. Kobayashi K, Suemasa F, Sagara H, Nakamura S, Ino Y, Kobayashi K, Hiramatsu H, Haraguchi T, Kurokawa K, Todo T, Nakano A, Iba H. MiR-199a inhibits secondary envelopment of Herpes Simplex Virus-1through the downregulation of Cdc42-specific GTPase activating protein localized in Golgi apparatus. Scientific Reports, 7:6650 (2017)
  3. Hiramatsu H, Kobayashi K, Kobayashi K, Haraguchi T, Ino Y, Todo T, Iba H. The role of the SWI/SNF chromatin remodeling complex in maintaining the stemness of glioma initiating cells. Scientific Reports, 7:889 (2017)
  4. Haraguchi T, Kondo M, Uchikawa R, Kobayashi K, Hiramatsu H, Kobayashi K, Ung CW, Shimizu T, and Iba H. Dynamics and plasticity of the epithelial to mesenchymal transition induced by miR-200 family inhibition. Scientific Reports, 6: 21117, 2016.
  5. Kobayashi K, Sakurai K, Hiramatsu H, Inada K, Shiogama K, Nakamura S, Suemasa F, Kobayashi K, Imoto S, Haraguchi T, Ito H, Ishizaka A, Tsutsumi Y, Iba H. The miR-199a/Brm/EGR1 axis is a determinant of anchorage-independent growth in epithelial tumor cell lines. Scientific Reports, 5: 8428, 2015.
  6. Tagawa T, Haraguchi T, Hiramatsu H, Kobayashi K, Sakurai K, Inada K, and Iba H. Multiple microRNAs induced by Cdx1 suppress Cdx2 in human colorectal tumor cells. Biochem. J. 447:449-455, 2012.
  7. Ishizaka A, Mizutani T, Kobayashi K, Tando T, Sakurai K, Fujiwara T, and Iba H. Double PHD finger proteins DPF3a and 3b are required as transcriptional coactivators in the SWI/SNF complex-dependent activation of the NF-kB RelA/p50 heterodimer. J. Biol. Chem. 287:11924-11933, 2012.