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Susumu Kawamoto

Position Visiting Professor
Research Projects Project for Molecular Signaling Analysis
Division Division of Clinical Research
TEL +81 43 226 2494
FAX +81 43 226 2486
E-mail kawamoto[at]faculty.chiba-u.jp
プロフィール写真

Specialities

Molecular and cellular medical mycology, Biochemistry, Molecar biology

Main topics of research

  1. Towards understanding cell cycle control in Cryptococcus neoformans
  2. Towards understanding hypoxia signaling in Cryptococcus neoformans

Main publications

  1. Shimizu K, Nakagawa H, Hashimoto R, Hagiwara D, Onji Y, Asano K, Kawamoto S, Takahashi H, Yokoyama K, The α–oxoamine synthase gene fum8 is involved in fumonisin B2 biosynthesis in Aspergillus niger. Mycoscience 56(3): 301-308, 2015.
  2. Takahashi-Nakaguchi A,Muraosa Y, Hagiwara D, Sakai K, Toyotome T, Watanabe A, Kawamoto S, Kamei K, Gonoi T, Takahashi H: Genome sequence comparison of Aspergillus fumigatus strains isolated from patients with pulmonary aspergilloma and chronic necrotizing pulmonary aspergillosis. Med Mycol, 53(4): 353-360, 2015.
  3. Toh-e A, Ohkusu M, Shimizu K, Kawamoto S: Positional cloning in Cryptococcus neoformans and its application for identification and cloning of the gene encoding methylenetetrahydrofolate reductase. Fungal Genet Biol 76: 70-7, 2015.
  4. Ueno K, Kinjo Y, Okubo Y, Aki K, Urai M, Kaneko Y, Shimizu K, Wang DN, Okawara A, Nara T, Ohkouchi K, Mizuguchi Y, Kawamoto S, Kamei K, Ohno H, Niki Y, Shibuya K, Miyazaki Y: Dendritic cell-based immunization ameliorates pulmonary infection with highly virulent Cryptococcus gattii. Infect Immun, 83(4): 1577-1586, 2015.
  5. Kopecká M, Yamaguchi M, Kawamoto S: The Effects of F-Actin Inhibitor Latrunculin A on Pathogenic Yeast Cryptococcus neoformans. Chemotherapy 60(3): 185-90, 2014.
  6. Moranova Z, Virtudazo E, Hricova K, Ohkusu M, Kawamoto S, Husickova V, Raclavsky V: The CRZ1/SP1-like gene links survival under limited aeration, cell integrity and biofilm formation in the pathogenic yeast Cryptococcus neoformans. Biomedical Papers 158(2): 212-220, 2014.
  7. Suganami A, Takase N, Sugiyama H, Virtudazo EV, Kawamoto S, Tamura Y: Structure based functional distinction between Cln1 and Cln2 depends on the ubiquitin-proteasome pathway. J Proteomics Bioinformatics 7(5): 102-107, 2014.
  8. Urayama S-I, Fukuhara T, Moriyama H, Toh-e A, Kawamoto S: Heterologous expression of a gene of Magnaporthe oryzae chrysovirus 1 strain A disrupts growth of the human pathogenic fungus Cryptococcus neoformans. Microbiol Immunol 58(5): 294–302, 2014.
  9. Shimizu K, Imanishi Y, Toh-e A, Uno J, Chibana H, Hull CM, Kawamoto S: Functional characterization of PMT2, encoding a protein-O-mannosyltransferase, in the human pathogen Cryptococcus neoformans. Fung Genet Biol 69: 13-22, 2014.
  10. D Hagiwara, A Takahashi-Nakaguchi, T Toyotome, A Yoshimi, K Abe, K Kamei, T Gonoi, S Kawamoto: NikA/TcsC Histidine Kinase Is Involved 1 in Conidiation, Hyphal Morphology, and Responses to Osmotic Stress and Antifungal Chemicals in Aspergillus fumigates. PloS ONE 8: e80881 (2013)
  11. L Kozubowski, V Yadav, G Chatterjee, S Sridhar, M Yamaguchi, S Kawamoto , I Bose, J Heitman, S Kaustuv : Ordered kinetochore assembly in the human fungal pathogen basidiomycetous yeast Cryptococcus neoformans. 　mBio 4(5) : e00614-13 (2013)
  12. M Kopecká, S Kawamoto, M Yamaguchi: A new F-actin structure in fungi: actin ring formation around the cell nucleus of Cryptococcus neoformans. Microscopy 62(2): 295–301 (2013)
  13. Y. Matsumoto, S. Miyazaki, D-H. Fukunaga, K. Shimizu, S. Kawamoto, K. Sekimizu:　Quantitative evaluation of cryptococcal pathogenesis and antifungal drugs using a silkworm infection model with Cryptococcus neoformans. Journal of Applied Microbiology 112: 138-146 (2012) 　
  14. EV. Virtudazo, A. Suganami, Y. Tamura, S. Kawamoto: Towards understanding cell cycle control in Cryptococcus neoformans: Structure-function relationship of G1 and G1/S cyclins homologue CnCln1. Biochemical and Biophysical Research Communications 416: 217-221 (2011)
  15. EV Virutudazo, S Kawamoto, M Ohkusu, S Aoki, M Sipiczki, K Takeo：The single Cdk1-G1 cyclin of Cryptococcus neoformans is not essential for cell cycle progression but has important roles in the proper commitment to DNA synthesis and bud emergence in this yeast. FEMS Yeast Research 10(5): 605-618　(2010)
  16. V Raclavsky, V Husickova, Z Moranova, M Ohkusu, O Fischer, J Precek, J Trtkova, K Takeo, S Kawamoto： Growth strategy of the pathogenic yeast Cryptococcus neoformans submerged culture under different cultivation formats. Folia Microbiologica 53(4): 349-352 (2009)
  17. V Raclavsky, J Pavlicek, R Novotny, Z Moranova, M Ohkusu, J Trtkova, K Takeo, S Kawamoto： Peculiar clusters of daughter cells oserved in Cryptococcus neoformans grown in sealed microtiter plates. Folia Microbiologica 53(4): 369-371 (2009)　
  18. T Takeuchi, G Ohtsuki, T Yoshida, M Fukaya, T Wainai, M Yamashita, Y Yamazaki, H Mori, K Sakimura, S Kawamoto, M Watanabe, T Hirano, M Mishina：Enhancement of both long-term depression induction and optokinetic response adaptation in mice lacking Delphilin. PLoS ONE, 3(5): e2297 (pp. 1-11) (2008)
  19. R Ikeda, F Saito, M Matsuo, K. Kurokawa, K Sekimizu, M Yamaguchi, S Kawamoto：　Contribution of the mannan backbone of cryptococcal glucuronoxylomannan and a glycolytic enzyme of Staphylococcus aureus to contact mediated killing of Cryptococcus neoformans. 　Journal of Bacteriology 189(13): 4815-4826 (2007)
  20. T Sonoda, M Mochizuki, T Yamashita, K Watanabe-Kaneko, Y Miyagi, Y Shigeri, F Yazama,,K Okuda, S Kawamoto： Binding of glutamate receptor δ2 to its scaffold protein is regulated by PKA. Biochemical and Biophysical Research Communication 348: 748-752 (2006)
  21. K Takeo, Y Ogura, E Virtudazo, V Raclavsky, S Kawamoto：Isolation of a CDC28 homologue from Cryptococcus neofoemans that is able to complement cdc28 temperature-sensitive mutants of Saccharomyces cerevisiae. 　FEMS Yeast Research 4(7): 737-744（2004）
  22. K Takeo, M Ohkusu, S Kawamoto：Effects of growth temperature upshift on cell cycle progression in Cryptococcus neoformans. 　Mycoscience 44: 465-471 (2003)
  23. Y Miyagi, T Yamashita, M Fukaya, T Sonoda, T Okuno, K Yamada, M Watanabe, Y Nagashima, I Aoki, K Okuda, M Mishina, S Kawamoto：Delphilin: a novel PDZ- and formin homology-domain containing protein, which synaptically colocalizes and interacts with glutamate receptor δ2 subunit. Journal of Neuroscience 22: 803-814 (2002)
  24. K Okuda, S Kawamoto, J Fukushima：Cytokine and costimulatory factor- encoding plasmids as adjuvants for DNA vaccination. Methods in Molecular Medicine (Vol. 29:　 “DNA Vaccines: Methods and Protocols”) pp. 197-204, Humana Press (2000)
  25. S Kawamoto, S Hattori, S Uchino, M Mishina, K Okuda：Expression of NMDA receptor channel subunit proteins using baculovirus and herpesvirus vectors.　Methods in Molecular Biology (Vol. 128: ”NMDA Receptor Protocols”) pp. 19-32, Humana Press (1999)
  26. S Kawamoto, Y Shibano, J Fukushima, N Ishii, K Morihar. K Okuda ：Site-directed mutagenesis of Glu-141 and His-223 in Pseudomonas aeruginosa elastase: catalytic activity, processing, and protective activity of the elastase against Pseudomonas infection. Infection and Immunity 61 : 1400-1405 (1993)
  27. Y Haraguchi, M Takiguchi, Y Amaya, S Kawamoto, I Matsuda, M. Mori：Molecular cloning and nucleotide sequence of cDNA for human liver arginase. ProcNatl Acad Sci USA 84 : 412-415 (1987)
  28. S Kawamoto, Y Amaya, K Murakami, F.Tokunaga, S Iwanaga, K Kobayashi, T Saheki, S Kimura, M Mori：Complete nucleotide sequence of cDNA and deduced amino acid sequence of rat liver arginase. Journal of Biological Chemistry 262 : 6280-6283 (1987)