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Naruhiko Ishiwada

Position Associate Professor
Research Projects Project for Infection Control and Prevention
Division Division of Infection Control and Prevention
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E-mail ishiwada[at]faculty.chiba-u.jp
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Specialities

Main topics of research

Main publications

  1. Muraki K, Kusama, Y, Takeuchi N, Ishiwada N. Secondary osteomyelitis from contiguous intrapelvic hematoma. Pediatr Int 2020 Nov;62(11):1301-1303.
  2. Takeuchi N, Ohkusu M, Hishiki H, Fujii K, Hotta M, Murata S, Ishiwada N. First report on multidrug-resistant non-encapsulated Streptococcus pneumoniae isolated from a patient with pneumonia J Infect Chemother :2020; 26: 749-51.
  3. Yamada N, Nakamoto T, Takei H, Shoji T, Takahashi K, Sato J, Takeuchi N, Ohkusu M, Ishiwada N. Two cases of bacterial meningitis due to meropenem-resistant Streptococcus pneumoniae: a threat of serotype 35B, ST 558 lineage. J Infect Chemother 2020; 26: 745-8.
  4. Furudate A, Hirose S, Abe K, Kawashima A, Hashimoto K, Yamazaki S, Kamei K, Ishiwada N, Hamada H, Sato M. Infantile Aspergillus fumigatus ventriculitis successfully treated with monitoring of plasma and cerebrospinal fluid voriconazole concentration level. J Infect Chemother. 2020; 26: 132-5.
  5. Takei H, Takeuchi N, Hoshino T, Ohkusu M, Segawa S, Murata S, Ishiwada N. Bacteriological analysis of Neisseria lactamica isolated from the respiratory tract in Japanese children. J Infect Chemother 2020. in press
  6. Takeshita K, Ishiwada N, Takeuchi N, Hishiki Hoshino T, Shimojo N. Haemophilus influenzae type b capsular polysaccharide antibody levels in Japanese young patients with hematological malignancies and asplenia J Infect Chemther 2020; 26: 959-62.
  7. Takeuchi N, Naito S, Ohkusu M, Abe K, Shizuno K, Takahashi Y, Omata Y, Nakazawa T, Takeshita K, Hishiki H, Hoshino T, Sato Y, Ishiwada N. Epidemiology of hospitalized paediatric community-acquired pneumonia and bacterial pneumonia following the introduction of 13-valent pneumococcal conjugate vaccine in the national immunization programme in Japan. Epidemiol Infect. 2020 Apr 17:1-53. doi: 10.1017/S0950268820000813.
  8. Ishiwada N, Suzuki C, Hasebe S, Tsuchiya A, Takeuchi N, Hishiki H, Sato Y, Sugita K. The effects of health education on health science teachers’ intention to recommend adolescent HPV vaccine for female students in Japan. Hum Vaccin Immunother. 2020 Mar 11:1-6. doi: 10.1080/21645515.2020.1732163. Online ahead of print.
  9. Fujita Y, Ishiwada N, Takei H, Suwabe SI, Yarita K, Ohkusu M, Muraosa Y, Kamei K, Shimojo N. Usefulness of gastric aspirate culture for diagnosing congenital immunodeficiency in an infant with fungal pneumonia caused by Rasamsonia piperina. Tohoku J Exp Med. 2019; 247: 265-9.
  10. Ogata H, Nagasawa K, Takeuchi N, Hagiwara S, Sawada D, Umimura T, Konno Y, Yamaide F, Takatani R, Takatani T, Nakano T, Hishiki H, Ishiwada N, Shimojo N. Psoitis and multiple venous thromboses caused by Panton Valentine Leukocidin-positive methicillin-sensitive Staphylococcus aureus in a 12-year-old girl: A case report. J Infect Chemother. 2019;25:630-4.
  11. Takei H, Ishiwada N, Hishiki H, Takeshita K, Naito S, Endo M, Shimojo N. Two pediatric cases of Pneumocystis jirovecii pneumonia diagnosed by polymerase chain reaction of gastric lavage. J Infect Chemother 2019;25: 477-9.
  12. Tonoi T, Inohana T, Sato T, Noda Y, Ikeda M, Akutsu M,Murata T,Maekawa Y, Tanaka A, Seki R, Ohkusu M, Kamei K, Ishiwada N, Shiina I. Total and Antimicrobial Evaluation of 23-Demethyleushearilide and Extensive Antimicrobial Evaluation of All Synthetic Stereoisomers of (16Z,20E)-Eushearilide and (16E,20E)-Eushearilide. Molecules 2019; 24(19). pii: E3437.
  13. Hoshino T, Takeuchi N, Ohkusu M, Hachisu Y, Hirose S, Fukasawa C, Kubota T, Ishida M, Watanabe H, Oishi K, Ishiwada N. Identification of Haemophilus influenzae serotype e strains missing the fucK gene in clinical isolates from Japan. J Med Microbiol. 2019; 68: 1534-9.
  14. Ohkusu M, Takeuchi N, Ishiwada N, Ohkusu K. Clonal spread of serotype 12F ST4846 Streptococcus pneumoniae. J Med Microbiol. 2019; 68:1383-90.
  15. Komatsu K, Kinai E, Sakamoto M, Taniguchi T, Nakao A, Sakata T, Iizuka A, Koyama T, Ogata T, Inui A, Oka S; HIV-Associated Neurocognitive Disorders in Japanese (J-HAND) Study Group (The J-HAND Study Group). Various associations of aging and long-term HIV infection with different neurocognitive functions: detailed analysis of a Japanese nationwide multicenter study. J Neurovirol. 2019; 25: 208-20.
  16. Takeuchi N, Ohkusu M, Wada N,Kurosawa S, Miyabe A,Yamaguchi M, Moon H Nahm MH, Ishiwada N. Molecular typing, antibiotic susceptibility, and biofilm production in nonencapsulated Streptococcus pneumoniae isolated from children in Japan. J Infect Chemother 2019; 25: 750-7.
  17. Yamazaki S, Fujiwara M, Inoue C, Watanabe M, Takayanagi S, Taniguchi T, Watanabe A, Ishiwada N, Igari H. Adverse events after the introduction of quadrivalent influenza vaccine in comparison with AH1pdm vaccine (2009) in Japan. Yakugaku-Zasshi 2019; 139: 469-74.
  18. Omura Y, Kusama Y, Takeuchi N, Ishiwada N. Mediastinal subcutaneous and multiple muscular abscesses after esophageal perforation caused by group B streptococcus serotype VIII in a type 2 diabetes mellitus patient. J Infect Chemother. 2018;24: 401-3.
  19. Suga S, Ishiwada N, Sasaki Y, Akeda H, Nishi J, Okada K, Fujieda M, Oda M, Asada K, Nakano T, Saitoh A, Hosoya M, Togashi T, Matsuoka M, Kimura K, Shibayama K. Nationwide population-based surveillance of invasive Haemophilus influenzae diseases in children after the introduction of the Haemophilus influenzae type b vaccine in Japan. Vaccine. 2018; 36: 5678-84.
  20. Naito S, Takeuchi N, Ohkusu M, Takahashi-Nakaguchi A, Takahashi H, Imuta N, Nishi J, Shibayama K, Matsuoka M, Sasaki Y, Ishiwada N. Clinical and bacteriologic analysis of nontypeable Haemophilus influenzae strains isolated from children with invasive diseases, Japan, 2008-2015. J Clin Microbiol 2018; 56. pii: e00141-18.
  21. Takeuchi N, Segawa S, Ishiwada N, Ohkusu M, Tsuchida S, Satoh M, Matsushita K, Nomura F. Capsular serotyping of Haemophilus influenzae by using matrix-associated laser desorption ionization-time of flight mass spectrometry. J Infect Chemother. 2018; 24: 510-4.
  22. Nagasawa K, Takeshita K, Taniguchi H, Suzuki H, Naito S, Hishiki H, Hoshino T, Kimura H, Suzuki, Shimojo N, Ishiwada N. Microfloral analysis of pediatric respiratory syncytial virus infection, with and without the use of antibiotics. Jpn J Antibiotics 2018; 71: 81-91.
  23. Sano T, Suzuki T, Nishigori A, Miyatake C, Koizumi S, Kaizu K, Fujita A, Kamisago M, Chang B, Ishiwada N, Asano T. The incidence of pediatric invasive bacterial diseases in Nippon Medical School Chiba Hokusoh Hospital before and after the introduction of conjugate vaccines. J Nippon Med Sch 2018; 85: 34-8.
  24. Takeshita K, Ishiwada N, Takeuchi N, Takahashi Y, Naito S, Nagasawa K, Hishiki H, Hoshino T, Shimojo N. Pneumococcal IgG levels against 13-valent pneumococcal conjugate vaccine serotypes in Japanese children with a medical history of hematopoietic neoplasms and solid tumors. Jpn J Antibitics 2018; 71: 13-21.
  25. Takei H, Ishiwada N, Takeuchi N, Ohkusu M, Hoshino T, Murata S, Sato H, Abe K, Shizuno K, Hishiki H, Shimojo N. Isolation rate of Neisseria meningitidis in Japanese children with respiratory tract infections. Jpn J Infect Dis. 2018; 71: 244-6.
  26. Ishiwada N, Kitajima H, Morioka I, Takeuchi N, Endo M, Watanabe A, Kamei K. Nationwide survey of neonatal invasive fungal infection in Japan. Med Mycol. 2018; 56: 679-86.
  27. Toh-E A, Ohkusu M, Shimizu K, Ishiwada N, Watanabe A, Kamei K. Novel biosynthetic pathway for sulfur amino acids in Cryptococcus neoformans. Curr Genet. 2018; 64: 681-96.
  28. Otsuka T, Hosokai R, Watanabe T, Ishiwada N, Saitoh A. Subcutaneous chest wall abscess as a complication of BCG vaccination. Pediatr Int. 2017;59: 1206-8. 【IF=1.139】
  29. Toh-E A, Ohkusu M, Shimizu K, Yamaguchi M, Ishiwada N, Watanabe A, Kamei K. Creation, characterization and utilization of Cryptococcus neoformans mutants sensitive to micafungin. Curr Genet. 2017; 63: 1093-104.
  30. Kimura H, Nagasawa K, Kimura R, Tsukagoshi H, Matsushima Y, Fujita K, Hirano E, Ishiwada N, Misaki T, Oishi K, Kuroda M, Ryo A. Molecular evolution of the fusion protein (F) gene in human respiratory syncytial virus subgroup B. Infect Genet Evol. 2017; 52:1-9.
  31. Hishiki H, Kameoka Y, Kato Y, Itoh R, Someya T, Inoue N, Haraki M, Kurosaki T, Suzuki S, OgawaT, Ishiwada N, Suzuki K. Molecular structure in gene mutation of neuraminidase of influenza virus type B isolated from swab of patients showing fever duration. ADC Letter for infectious Disease Control 2017; 4: 18-23.
  32. Takeuchi N, Ohkusu M, Hoshino T, Naito S, Takaya A, Yamamoto T, Ishiwada N. Emergence of quinolone-resistant strains in Streptococcus pneumoniae isolated from paediatric patients since the approval of oral fluoroquinolones in Japan. J Infect Chemother. 2017; 23: 218-23.
  33. Igari H, Watanabe A, Ichimura Y, Sakurai T, Taniguchi T, Ishiwada N. Quality control in QuantiFERON-TB gold in-tube for screening latent tuberculosis infection in health care workers. J Infect Chemother. 2017; 23: 211-3.
  34. Toh-E A, Ohkusu M, Shimizu K, Takahashi-Nakaguchi A, Kawamoto S, Ishiwada N, Watanabe A, Kamei K. Putative orotate transporter of Cryptococcus neoformans, Oat1, is a member of the NCS1/PRT transporter super family and its loss causes attenuation of virulence. Curr Genet. 2016; 63: 697-707.
  35. Nakano T, Ishiwada N, Sumitani T, Uemori M, Isobe K; Laninamivir Prophylaxis Study Group. Inhaled Laninamivir Octanoate as Prophylaxis for Influenza in Children. Pediatrics. 2016 Dec;138(6). pii: e20160109.
  36. Hoshino T, Takeuchi N, Fukasawa C, Hirose S, Okui H, Sato H, Sato M, Arimoto Y, Nakano A, Ishiwada N. Analysis of Streptococcus pneumoniae and Haemophilus influenzae isolated from middle ear fluid before and after the introduction of government subsidies for pneumococcal and H. influenzae type b vaccines in Japan. J Infect Chemother. 2017; 23: 85-9.
  37. Ishiwada N, Watanabe M, Murata S, Takeuchi N, Taniguchi T, Igari H. Clinical and bacteriological analyses of bacteremia due to Corynebacterium striatum. J Infect Chemother; 22(12):790-793, 2016.
  38. Sano G, Itagaki T, Ishiwada N, Matsubara K, Iwata S, Nakamori Y, Matsuyama K, Watanabe K, Ishii Y, Homma S, Tateda K. Characterization and Evaluation of Newly Developed Immune-Chromatographic Method Targeting Mycoplasma pneumoniae Ribosomal Protein L7/L12. J Med Microbiol, 2016 Aug 19. doi:10.1099/jmm.0.000336. [Epub ahead of print]
  39. Nagasawa K, Ishiwada N, Ogura A, Ogawa T, Takeuchi N, Hishiki H, Shimojo N. Congenital Rubella Syndrome: A Case Report on Changes in Viral Load and Rubella Antibody Titers. Pediatrics. 137: e20153333, 2016.
  40. Ishiwada N, Takaya A, Kimura A, Watanabe M, Hino M, Ochiai H, Matsui M, Shibayama K, Yamamoto T. Linezolid-resistant Staphylococcus epidermidis associated with long-term, repeated linezolid use in a pediatric patient. J Infect Chemother ; 22(3):187-90, 2016.
  41. Ishiwada N, Takeshita K, Yaguchi T, Nagasawa K, Takeuchi N, Hishiki H, Watanabe A, Kamei K, Shimojo N: The first case of invasive mixed-mold infections due to Emericella nidulans var. echinulata and Rasamsonia piperina in a patient with chronic granulomatous disease. Mycopathologia 181(3-4): 305-9, 2016.
  42. Nagasawa K, Hirano E, Kobayashi M, Ryo A, Oishi K, Obuchi M, Ishiwada N, Noda M, Kuroda M, Shimojo N, Kimura H. Molecular evolution of the hypervariable region of the attachment glycoprotein gene in human respiratory syncytial virus subgroup B genotypes BA9 and BA10. Infect Genet Evol ; 36:217-223, 2015.
  43. Suga S, Chang B, Asada K, Akeda H, Nishi J, Okada K, Wakiguchi H, Maeda A, Oda M, Ishiwada N, Saitoh A, Oishi T, Hosoya M, Togashi T, Oishi K, Ihara T. Nationwide population-based surveillance of invasive pneumococcal disease in Japanese children: Effects of the seven-valent pneumococcal conjugate vaccine. Vaccine, pii: S0264-410X(15)01038-5, 2015.
  44. Naito S, Tanaka J, Nagashima K, Chang B, Hishiki H, Takahashi Y, Oikawa J, Nagasawa K, Shimojo N, Ishiwada N. The impact of heptavalent pneumococcal conjugate vaccine on the incidence of childhood community-acquired pneumonia and bacteriologically confirmed pneumococcal pneumonia in Japan. Epidemiol Infect. 30: 1-13, 2015
  45. Mori M, Imaizumi M, Ishiwada N, Kaneko T, Goto H, Kato K, Hara J, Kosaka Y, Koike K, Kawamoto H, Maeda N, Yoshinari T, Kishino H, Takahashi K, Kawahara S, Kartsonis NA, Komada Y. Pharmacokinetics, efficacy, and safety of caspofungin in Japanese pediatric patients with invasive candidiasis and invasive aspergillosis. J Infect Chemother. 21(6): 421-6, 2015
  46. Hoshino T, Hachisu Y, Kikuchi T, Tokutake S, Okui H, Kutsuna S, Fukasawa C, Murayama K, Oohara A, Shimizu H, Ito M, Takahashi Y, Ishiwada N. Analysis of Haemophilus influenzae serotype f isolated from three Japanese children with invasive H. influenzae infection. J Med Microbiol. 64(Pt 4): 355-8, 2015
  47. Takaya A, Kimura A, Sato Y, Ishiwada N, Watanabe M, Matsui M, Shibayama K, Yamamoto T. Molecular characterization of linezolid-resistant CoNS isolates in Japan. J Antimicrob Chemother. 70:658-663, 2015
  48. Oikawa J, Ishiwada N, Takahashi Y, Hishiki H, Nagasawa K, Takahashi S, Watanabe M, Chang B, Kohno Y.Changes in nasopharyngeal carrage of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis among healthy children attending a day-care center official financial support for the 7-valent pneumococcal conjugate vaccine and Haemophilus influenzae type b vaccine in Japan. J Infect Chemother.20: 146-149, 2014
  49. Qin L, Kida Y, Ishiwada N, Ohkusu K, Kaji C, Sakai Y, Watanabe K, Furumoto A, Ichinose A, Watanabe H. The relationship between biofilm formations and capsule in Haemophilus influenzae.J Infect Chemother. 20: 151-156, 2014
  50. Tamura K, Matsubara K, Ishiwada N, Nishi J, Ohnishi H, Suga S, Ihara T, Chang B, Akeda Y, Oishi K; Japanese IPD Study Group. Hyporesponsiveness to the infecting serotype after vaccination of children with seven-valent pneumococcal conjugate vaccine following invasive pneumococcal disease. Vaccine. 32: 1444-1450, 2014
  51. Takahashi Y, Ishiwada N, Hishiki H, Tanaka J, Akeda Y, Shimojo N, Oishi K, Kohno Y.IgG levels against 13-valent pneumococcal conjugate vaccine serotypes in non pneumococcal conjugate vaccine immunized healthy Japanese and intravenous immunoglobulin preparations.J Infect Chemother. 20:794-798,2014
  52. Chang B, Wada A, Hosoya M, Oishi T, Ishiwada N, Oda M, Sato T, Terauchi Y, Okada K, Nishi J, Akeda H, Kamiya H, Ohnishi M, Ihara T; Japanese Invasive Disease Study Group. Characteristics of group B streptococcus isolated from infants with invasive infections: a population-based study in Japan. Jpn J Infect Dis. 67: 356-60, 2014
  53. Ishiwada N, Hishiki H, Nagasawa K, Naito S, Sato Y, Chang B, Sasaki Y, Kimura K, Ohnishi M, Shibayama K. The incidence of pediatric invasive Haemophilus influenzae and pneumococcal disease in Chiba prefecture, Japan before and after the introduction of conjugate vaccines.Vaccine. 32: 5425-31, 2014
  54. Oikawa J, Tanaka J, Yoshikawa T, Morita Y, Hishiki H, Ishiwada N, Ohya T, Kurahashi H, Kohno Y. An immunocompetent child with chromosomally integrated human herpes virus 6B accidentally identified during the case of Mycoplasma pneumoniae infection. J Infect Chemother 20: 65-67, 2014
  55. Takahashi Y, Ishiwada N, Tanaka J, Ohkusu K, Ichimura S, Hishiki H, Ota S, Kohno Y. Streptococcus gallolyticus subsp. pastrianus meningitis in an infant. Pediatr Int 56: 282-285, 2014
  56. Oishi T, Ishiwada N, Matsubara K, Nishi J, Chang B, Tamura K, Akeda Y, Ihara T, Nahm MH, Oishi K.the Japanese IPD Study Group. Low opsonic activity to the infecting serotype in pediatric patients with invasive pneumococcal disease. Vaccine. 31:845-849,2013
  57. Kuroki H, Ishiwada N, Inoue N, Ishikawa N, Suzuki H, Himi K, Kurosaki T.Comparison of clinical efficacy between 3-day combined clavulanate/amoxicillin preparation treatment and 10-day amoxicillin treatment in children with pharyngolaryngitis or tonsillitis. J Infect Chemother. 19:12-19,2013
  58. Madhi SA, De Wals P, Grijalva CG, Grimwood K, Grossman R, Ishiwada N, Lee PI, Nascimento-Carvalho C, Nohynek H, O'Brien KL, Vergison A, Wolter J. The Burden of Childhood Pneumonia in the Developed World: A Review of the Literature. Pediatr Infect Dis J. 32: e119-e127,2013
  59. Ishiwada N, Tokunaga O, Nagasawa K, Ichimoto K, Kinoshita K, Hishiki H, Kohno Y.Isoniazid- and streptomycin-resistant miliary tuberculosis complicated by intracranial tuberculoma in a Japanese infant. Tohoku J Exp Med. 229: 221-5,2013
  60. Tanaka J, Kurosaki T, Shimada A, Kameyama Y, Mitsuda T, Ishiwada N, Kohno Y. Complications of adenotonsillectomy: a case report of meningitis due to dual infection with nontypeable Haemophilus influenzae and Streptococcus pneumoniae, and a prospective study of the rate of postoperative bacteremia. JJA 66: 205-210,2013
  61. Sugiyama A, Mori M, Ishiwada N, Himuro K, Kuwabara S.First adult case of Helicobacter cinaedi meningitis. J Neurol Sci. 336: 263-264,2013
  62. Ishiwada N, Takada N, Okunushi T, Hishiki H, Katano H, Nakajima N, Kohno Y. Rhabdomyolysis associated with influenza A/H1N1 2009 infection in a pediatric patient. Pediatr Int 54: 703-705,2012
  63. Koga S, Ishiwada N, Honda Y, Okunushi T, Hishiki H, Ouchi K, Kohno Y. A case of meningoencephalitis associated with macroride-resistant Mycoplasma pneumoniae infection. 54:724-726,2012
  64. Okada T, Morozumi M, Sakata H, Takayanagi R, Ishiwada N, Sato Y, Oishi T, Tajima T, Haruta T, Kawamura N, Ouchi K, Matsubara K, Chiba N, Takahashi T, Iwata S, Ubukata K. A practical approach estimating etiologic agents using real-time PCR in pediatric inpatients with community-acquired pneumonia J Infect Chemother 18: 832-840,2012
  65. Tsuda K, Iwasaki S, Horiguchi H, Mori M, Nishimaki S, Seki K, Taguri M, Yokota S, Ishiwada N.Immune response to Haemophilus influenzae type b conjugate vaccine in preterm infants. Pediatr Int. 54: 64-67,2012
  66. Tanaka J, Ishiwada N, Wada A, Chang B, Hishiki H, Kurosaki T, Kohno Y. Incidence of childhood pneumonia and serotype and sequence-type distribution in Streptococcus pneumoniae isolates in Japan. Epidemiol Infect. 30: 1111-1121,2012
  67. Hoshino T, Ishiwada N, Kohno Y. Restriction fragment length polymorphism analysis of Haemophilus influenzae type b strains isolated simultaneously from cerebrospinal fluid, blood, and nasopharynx of Japanese children with bacterial meningitis Chiba Medical Journal 88: 35-39,2012
  68. Hishiki H, Ishiwada N, Fukasawa C, Abe K, Hoshino T, Aizawa J, Ishikawa N, Kohno Y.Incidence of bacterial coinfection with respiratory syncytial virus bronchopulmonary infection in pediatric inpatients. J Infect Chemother. 17:87-90,2011
  69. Ishiwada N, Honda Y, Tanaka J, Hishiki H, Kohno Y. Anti-polyribosylribitol phosphate antibody in pediatric patients with Haemophilus influenzae type b invasive disease. J Infect Chemother 17: 397-400,2011