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Hideo Iba

Position Visiting Professor
Research Projects Project for RNA regulation
Division Joint Division of RNA Therapy
TEL +81 43 226 2801
E-mail iba[at]


Molecular Biology, Virology

Main topics of research

Analysis of gene regulatory networks formed by miRNAs and transcription factors and development of RNA therapy based upon these network analysis.

Main publications

  1. Kobayashi K*, Hiramatsu H*, Nakamura S, Kobayashi K, Haraguchi T, Iba, H. (* equally contrbuted) Tumor suppression via inhibition of SWI/SNF complex-dependent NF-κB activation. Scientific Reports, 7:11772 (2017)
  2. Kobayashi K, Suemasa F, Sagara H, Nakamura S, Ino Y., Kobayashi K, Hiramatsu H, Haraguchi T, Kurokawa K, Todo T, Nakano A, Iba H. MiR-199a Inhibits Secondary Envelopment of Herpes Simplex Virus-1 Through the Downregulation of Cdc42-specific GTPase Activating Protein Localized in Golgi Apparatus. Scientific Reports, 7:6650 (2017)
  3. Hiramatsu H, Kobayashi K, Kobayashi K, Haraguchi T, Ino Y, Todo T, Iba H. The role of the SWI/SNF chromatin remodeling complex in maintaining the stemness of glioma initiating cells. Scientific Reports 7:889 (2017)
  4. Haraguchi T, Kondo M, Uchikawa R, Kobayashi K, Hiramatsu H, Kobayashi K, Chit UW, Shimizu T, Iba H. Dynamics and plasticity of the epithelial to mesenchymal transition induced by miR-200 family inhibition. Scientific Reports. 6:21117. (2016)
  5. Kobayashi K, Sakurai K, Hiramatsu H, Inada K, Shiogama K, Nakamura S, Suemasa F, Kobayashi K, Imoto S, Haraguchi T, Ito H, Ishizaka A, Tsutsumi Y, Iba H. The miR-199a/Brm/EGR1 axis is a determinant of anchorage-independent growth in epithelial tumor cell lines. Scientific Reports, 5:8428 (2015)
  6. Mizutani T, Ishizaka A, Suzuki Y, Iba H. 7SK small nuclear ribonucleoprotein complex is recruited to the HIV-1 promoter via short viral transcripts. FEBS Letters, 588:1630-1636 (2014)
  7. Siddesha J.M, Valente A.J, Yoshida T, Sakamuri S.S.V.P, Delafontaine P, Iba H, Noda M, Chandrasekar B. Docosahexaenoic acid reverses angiotensin II-induced RECK suppression and cardiac fibroblast migration. Cellular Signalling, 26:933-941 (2014)
  8. Kurashima Y, Amiya T, Nochi T, Fujisawa K, Haraguchi T, Iba H, Tsutsui H, Sato S, Nakajima S, Iijima H, Kubo M, Kunisawa J, Kiyono H. Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors. Nature Communications, 3:1034 (2012)
  9. Ishizaka A, Mizutani T, Kobayashi K, Tando T, Sakurai K, Fujiwara T, Iba H. Double PHD finger proteins DPF3a and 3b are required as transcriptional coactivators in the SWI/SNF complex-dependent activation of the NF-kB RelA/p50 heterodimer. J. Biol. Chem. 287:11924-11933 (2012)
  10. Haraguchi T, Nakano H, Tagawa T, Ohki T, Ueno Y, Yoshida T, Iba H. A potent 2’-O-methylated RNA-based microRNA inhibitor with unique secondary structures. Nucleic Acids Res. 40:e58 (2012)
  11. Hikichi M, Kidokoro M, Haraguchi T, Iba H, Shida H, Tahara H, Nakamura T. MicroRNA regulation of glycoprotein B5R in oncolytic vaccinia virus reduces viral pathogenicity without impairing its antitumor efficacy. Molecular Therapy, 19: 1107-1115 (2011)
  12. Sakurai K, Furukawa C, Haraguchi T, Inada K, Shiogama K, Tagawa T, Fujita S, Ueno Y, Ogata A, Ito M, Tsutsumi Y, Iba H. microRNAs miR-199a-5p and -3p target the Brm subunit of SWI/SNF to generate a double-negative feedback loop in a variety of human cancers. Cancer Res. 71:1680-1689 (2010)
  13. Tando T, Ishizaka A, Watanabe H, Ito T, Iida S, Haraguchi T, Mizutani T, Izumi T, Isobe T, Akiyama T, Inoue J, Iba H. Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a non-canonical NFκB pathway. J. Biol. Chem., 285: 21951-21960 (2010)
  14. Mizutani T, Ishizaka A, Tomizawa M, Okazaki T, Yamamichi N, Kawana-Tachikawa A, Iwamoto A, Iba H. Loss of the Brm-type SWI/SNF chromatin remodeling complex is a strong barrier to the Tat-independent transcriptional elongation of HIV-1 transcripts. J. Virol., 83:11569-11580. (2009)
  15. Yamamichi N, Shimomura R, Inada K, Sakurai K, Haraguchi T, Ozaki Y, Fujita S, Mizutani T, Furukawa C, Fujishiro M, Ichinose M, Shiogama K, Tsutsumi Y, Omata M, Iba H. LNA in situ hybridization analysis of miR-21 expression during colorectal cancer development. Clin. Cancer Res., 15:4009-4016. (2009)
  16. Yamamichi N, Inada K, Furukawa C, Sakurai K, Tando T, Ishizaka A, Haraguchi T, Mizutani T, Fujishiro M, Shimomura R, Oka M, Ichinose M, Tsutsumi Y, Omata M, Iba H. Cdx2 and the Brm-type SWI/SNF complex cooperatively regulate villin expression in gastrointestinal cells. Exp. Cell Res., 315:1779-1789. (2009)
  17. Haraguchi T, Ozaki Y, Iba H. Vectors expressing efficient RNA decoys achieve the long-term suppression of specific microRNA activity in mammalian cells. Nucleic Acids Res., 37:e43. (2009)
  18. Fujita S, Ito T, Mizutani T, Minoguchi S, Yamamichi N, Sakurai K, Iba H. Mir-21 gene expression triggered by AP-1 is sustained through a double negative feedback mechanism. J. Mol. Biol., 378:492-504. (2008)
  19. Minoguchi S, Iba H. Instability of retroviral DNA methylation in embryonic stem cells. Stem Cells, 26:1166-1173. (2008)
  20. Kayama H, Ramirez-Carrozzi V. R, Yamamoto M, Mizutani T, Kuwata H, Iba H, Matsumoto M, Honda K, Smale S.T, Takeda K. Class-specific regulation of pro-inflammatory genes by MYD88 pathways and IκBζ. J. Biol. Chem., 283:12468-12477. (2008)
  21. Fujita S, Iba H. Putative promoter regions of miRNA genes involved in evolutionarily conserved regulatory systems among vertebrates. Bioinformatics, 24:303-308. (2008)
  22. Ito T, Yamauchi M, Nishina M, Yamamichi N, Mizutani T, Ui M, Murakami M, Iba H. Identification of SWI/SNF complex subunit BAF60a as a determinant of transactivation potential of Fos/Jun dimers. J. Biol. Chem. 276: 2852-2857 (2001)
  23. Nishina H, Sato H, Suzuki T, Sato M, Iba H. Isolation and characterization of fra-2: a new member of fos gene family. Proc. Natl. Acad. Sci. USA 87: 3619-3623 (1990)
  24. Iba H, Takeya T, Cross F. R, Hanafusa T, Hanafusa H. Rous sarcoma virus variants which carry the cellular src gene instead of the viral src gene cannot transform chicken embryo fibroblasts. Proc. Natl. Acad. Sci. USA 81: 4424-4428 (1984)