山崎晶

専門分野

免疫学、細菌学

研究テーマ

1. 免疫受容体を介する自己・非自己認識機構とその意義の解明

所属学協会

日本免疫学会、日本細菌学会、日本生化学会、日本癌学会、日本農芸学会、日本農芸化学会

主な発表論文、著書

1. Miyake Y, Toyonaga K, Mori D, Kakuta S, Hoshino Y, Oyamada A, Yamada H, Ono K, Suyama M, Iwakura Y, Yoshikai Y, Yamasaki S: C-type lectin MCL is an FcRγ-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor. Immunity 38:1050-62, 2013.
2. Ishikawa T, Itoh F, Yoshida S, Saijo S, Matsuzawa T, Gonoi T, Saito T, Okawa Y, Shibata N, Miyamoto T, and Yamasaki S: Identification of distinct ligands for the C-type lectin receptors Mincle and Dectin-2 in the pathogenic fungus Malassezia. Cell Host Microbe 13:477-88. 2013
3. Furukawa A, Kamishikiryo J, Mori D, Toyonaga K, Okabe Y, Toji A, Kanda R, Miyake Y, Ose T, Yamasaki S, and Maenaka K: Structural analysis for glycolipid recognition by the C-type lectins Mincle and MCL. Proc. Natl. Acad. Sci. USA. 110:17438-43. 2013
4. Ishikawa E, Miyake Y, Hara H, Saito T, Yamasaki S: Germ-line elimination of electric charge on pre-T-cell receptor (TCR) impairs autonomous signaling for β-selection and TCR repertoire formation. Proc. Natl. Acad. Sci. USA. 107:19979-84, 2010.
5. Ishikawa E, Ishikawa T, Morita YS, Toyonaga K, Yamada H, Takeuchi O, Kinoshita T, Akira S, Yoshikai Y, Yamasaki S: Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle. J. Exp. Med. 206:2879-88, 2009.
6. Yamasaki, S., Ishikawa, E., Sakuma, M., Hara, H., Ogata, K. and Saito T: Mincle is an ITAM-coupled activating receptor that senses damaged cells. Nat. Immunol. 9: 1179-1188, 2008.
7. Yamasaki, S. Ishikawa, E., Sakuma, M., Ogata, K., Sakata-Sogawa, K., Hiroshima, M., Wiest, D.L., Tokunaga, M. and Saito, T: Mechanistic basis of pre-T cell receptor-mediated autonomous signaling critical for thymocyte development. Nat. Immunol. 7: 67-75, 2006.

研究

• 研究分野・プロジェクト研究
• 研究者リスト