研究
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笹川千尋

職種 特任教授・センター長
所属プロジェクト
研究部門
分野
TEL 043-226-2487
FAX 043-226-2486
E-mail sasakawa[at]ims.u-tokyo.ac.jp
プロフィール写真

専門分野

細菌学、感染生物学、自然免疫学、細胞生物学

研究テーマ

細菌感染戦略と自然免疫応答の解明とその応用

所属学協会

日本免疫学会、日本細菌学会

主な発表論文、著書

  1. Suzuki S, Mimuro H, Kim M, Ogawa M, Ashida H, Toyotome T, Franchi L, Suzuki M, Sanada T, Suzuki T, Tsutsui H, Núñez G, Sasakawa C. Shigella IpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages. Proc Natl Acad Sci USA. 111(40):E4254-63, 2014.
  2. Kiga K, Mimuro H, Suzuki M, Shinozaki-Ushiku A, Kobayashi T, Sanada T, Kim M, Ogawa M, Iwasaki YW, Kayo H, Fukuda-Yuzawa Y, Yashiro M, Fukayama M, Fukao T, Sasakawa C. Epigenetic silencing of miR-210 increases the proliferation of gastric epithelium during chronic Helicobacter pylori infection. Nat Communication, 5:4497, 2014.
  3. Ashida H, Kim M, Sasakawa C. Exploitation of the host ubiquitin system by bacterial pathogens. Nat Rev Microbiol, 12(6): 399-413, 2014.
  4. Kobayashi T, Ogawa M, Sanada T, Mimuro H, Kim M, Ashida H, Akakura R, Yoshida M, Kawalec M, Reichhart JM, Mizushima T, Sasakawa C. The Shigella OspC3 effector inhibits caspase-4, antagonizes inflammatory cell death, and promotes epithelial infection. Cell Host Microbe. 13(5):570-83, 2013.
  5. Fukumatsu M, Ogawa M, Arakawa S, Suzuki M, Nakayama K, Shimizu S, Kim M, Mimuro H, Sasakawa C. Shigella targets epithelial tricellular junctions and uses a noncanonical clathrin-dependent endocytic pathway to spread between cells. Cell Host Microbe. 11(4):325-36, 2012.
  6. Sanada T, Kim M, Mimuro H, Suzuki M, Ogawa M, Oyama A, Ashida H, Kobayashi T, Koyama T, Nagai S, Shibata Y, Gohda J, Inoue J, Mizushima T, Sasakawa C. The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response. Nature. 483(7391):623-6, 2012.
  7. Ashida H, Ogawa M, Kim M, Mimuro H, Sasakawa C. Bacteria and host interactions in the gut epithelial barrier. Nat Chem Biol. 8(1):36-45, 2011.
  8. Ashida H, Mimuro H, Ogawa M, Kobayashi T, Sanada T, Kim M, Sasakawa C. Cell death and infection: a double-edged sword for host and pathogen survival. J Cell Biol. 195(6):931-42, 2011.
  9. Ogawa M, Yoshikawa Y, Kobayashi T, Mimuro H, Fukumatsu M, Kiga K, Piao Z, Ashida H, Yoshida M, Kakuta S, Koyama T, Goto Y, Nagatake T, Nagai S, Kiyono H, Kawalec M, Reichhart JM, Sasakawa C. A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens. Cell Host Microbe. 9(5):376-89, 2011.
  10. Kim M, Ashida H, Ogawa M, Yoshikawa Y, Mimuro H, Sasakawa C. Bacterial interactions with the host epithelium. Cell Host Microbe. 8(1):20-35, 2010.
  11. Ashida H, Kim M, Schmidt-Supprian M, Ma A, Ogawa M, Sasakawa C. A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKgamma to dampen the host NF-kappaB-mediated inflammatory response. Nat Cell Biol. 12(1):66-73, 2010.