研究
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村長保徳

職種 特任助教
所属プロジェクト 臨床感染症プロジェクト
研究部門 真菌症研究部門
分野 臨床感染症分野
TEL 043-226-2785
FAX 043-226-2486
E-mail muraosa[at]faculty.chiba-u.jp
プロフィール写真

専門分野

獣医真菌学、医真菌学、分子生物学

研究テーマ

  1. Real-time PCR法を用いた真菌症の新規診断法の開発
  2. Aspergillus fumigatusの病原因子の機能解析
  3. フザリウム症起因菌の分子疫学
  4. 海生動物の真菌症に関する研究

所属学協会

日本医真菌学会、日本感染症学会

主な発表論文、著書

  1. Hino Y, Muraosa Y, Oguchi M, Yahiro M, Yarita K, Watanabe A, Sakaida E, Yokote K, Kamei K: Drain outlets in patient rooms as sources for invasive fusariosis: an analysis of patients with haematological disorders. J Hosp Infect, S0195-6701(20)30204-8, 2020.
  2. Hoshino A, Tokoro S, Akashi T, Inoue M, Takagi M, Imai K, Kanegane H, Muraosa Y, Kamei K, Morio T: Disseminated fusariosis in a child after haploidentical hematopoietic stem cell transplantation. Pediatr Int, 62: 419-420, 2020.
  3. Nakamura A, Tawara I, Ino K, Matsumoto T, Hayashi A, Imai H, Muraosa Y, Kamei K, Katayama N: Achievement of long-term remission of disseminated histoplasmosis in an AIDS patient. Med Mycol Case Rep, 27: 25-28, 2020.
  4. Hanashiro J, Muraosa Y, Toyotome T, Hirose K, Watanabe A, Kamei K: Schizophyllum commune induces IL-17-mediated neutrophilic airway inflammation in OVA-induced asthma model mice. Sci Rep, 9(1):19321, 2019.
  5. Muraosa Y, Toyotome T, Yahiro M, Kamei K: Characterisation of novel-cell-wall LysM-domain proteins LdpA and LdpB from the human pathogenic fungus Aspergillus fumigatus. Sci Rep, 9(1):3345, 2019.
  6. Fujita Y, Ishiwada N, Takei H, Suwabe S, Yarita K, Ohkusu M, Muraosa Y, Kamei K, Shimojo N: Usefulness of Gastric Aspirate Culture for Diagnosing Congenital Immunodeficiency in an Infant with Fungal Pneumonia Caused by Rasamsonia piperina. Tohoku Journal of Experimental Medicine, 247, 265-269, 2019.
  7. Moretti ML, Busso-Lopes AF, Tararam CA, Moraes R, Muraosa Y, Mikami Y, Gonoi T, Taguchi H, Lyra L, Reichert-Lima F, Trabasso P, de Hoog GS, Al-Hatmi AMS, Schreiber AZ, Kamei K: Airborne transmission of invasive fusariosis in patients with hematologic malignancies. Plos One, 13(4):e0196426, 2018.
  8. Fujimoto M, Inaba Y, Takahashi T, Nakanishi G, Muraosa Y, Yahiro M, Kamei K, Murata S: Image Gallery: Granulomatous dermatitis due to infection with the chlorophyllic green alga Desmodesmus. British Journal of Dermatology, 179, E167-E167, 2018.
  9. Okada K, Endo T, Hashimoto D, Saga T, Ara T, Ogasawara R, Yasumoto A, Ibata M, Takahata M, Shigematsu A, Kondo T, Muraosa Y, Nomura T, Kanno-Okada H, Hashino S, Tanaka S, Kamei K, Teshima T: Disseminated fusariosis emerged from prolonged local genital infection after cord blood transplantation. J Infect Chemother, 24(8):660-663, 2018.
  10. Uemura S, Tamura A, Yamamoto N, Saito A, Nakamura S, Fujiwara T, Tahara T, Kozaki A, Kishimoto K, Ishida T, Hasegawa D, Muraosa Y, Kamei K, Kosaka Y: Successful Combination Therapy of Liposomal Amphotericin B and Caspofungin for Disseminated Fusariosis in a Pediatric Patient with Acute Lymphoblastic Leukemia. Pediatr Infect Dis J, 37(10):e251-e253, 2018.
  11. 黒澤 修兵, 関谷 紀貴, 村長 保憲, 亀井 克彦, 永田 啓人, 山田 裕太, 小西 達矢, 竹崎 俊晶, 海渡 智史, 阪口 正洋, 原田 介斗, 安田 俊一郎, 吉岡 康介, 稲本 恭子, 遠矢 嵩, 五十嵐 愛子, 名島 悠峰, 武藤 秀治, 土岐 典子, 小林 武, 垣花 和彦, 坂巻 壽, 大橋 一輝: 急性白血病の経過中に播種性フザリム症を発症した3例の後方視的検討. 臨床血液, 58: 2375-2379, 2017.
  12. Muraosa Y, Oguchi M, Yahiro M, Watanabe A, Yaguchi T, Kamei K: Epidemiological study of Fusarium species causing invasive and superficial fusariosis in Japan. Med Mycol J, 58, E5-e13, 2017.
  13. de Souza M, Matsuzawa T, Sakai K, Muraosa Y, Lyra L, Busso-Lopes AF, Levin ASS, Schreiber AZ, Mikami Y, Gonoi T, Kamei K, Moretti ML, Trabasso P: Comparison of DNA Microarray, Loop-Mediated Isothermal Amplification (LAMP) and Real-Time PCR with DNA Sequencing for Identification of Fusarium spp. Obtained from Patients with Hematologic Malignancies. Mycopathologia, 182: 625-632, 2017.
  14. Hirayama T, Takazono T, Iwata K, Senju H, Shimazaki T, Tashiro M, Saijo T, Tanaka T, Nakamura S, Imamura Y, Kojiro M, Miyazaki T, Tsukamoto M, Furumoto A, Morimoto K, Muraosa Y, Matsubara Y, Yanagihara K, Mukae H, Kamei K, Kohno S, Izumikawa K: A case series of histoplasmosis patients with elevated serum soluble interleukin-2 receptor levels. J Infect Chemother 23: 642-647, 2017.
  15. 浅井 幸, 吉見 公佑, 竹中 基 宇谷 厚志, 村長 保憲, 亀井 克彦, 西本 勝太郎: 症例 急性骨髄性白血病治療中に生じたFusarium感染症の1例.皮膚科の臨床, 59: 105-109, 2017.
  16. Muraosa Y, Toyotome T, Yahiro M, Watanabe A, Shikanai-Yasuda MA, Kamei K: Detection of Histoplasma capsulatum from clinical specimens by cycling probe-based real-time PCR and nested real-time PCR. Med Mycol, 54(4): 433-8, 2016.
  17. 田子(浅畑)さやか, 平井 由児, 相野田 祐介, 藤田 崇宏, 村長 保憲, 亀井 克彦, 若山 恵, 渋谷 和俊, 菊池 賢: メキシコ渡航中に感染したと推定される肺ヒストプラズマ症の男性と配偶者への対応. 感染症学雑誌, 90: 83-87, 2016.
  18. Trabasso P, Matsuzawa T, Fagnani R, Muraosa Y, Tominaga K, Resende MR, Kamei K, Mikami Y, Schreiber AZ, Moretti ML: Isolation and Drug Susceptibility of Candida parapsilosis Sensu Lato and other Species of C-parapsilosis Complex from Patients with Blood Stream Infections and Proposal of a Novel LAMP Identification Method for the Species. Mycopathologia 179(1-2): 53-62, 2015.
  19. Takahashi-Nakaguchi A, Muraosa Y, Hagiwara D, Sakai K, Toyotome T, Watanabe A, Kawamoto S, Kamei K, Gonoi T, Takahashi H: Genome sequence comparison of Aspergillus fumigatus strains isolated from patients with pulmonary aspergilloma and chronic necrotizing pulmonary aspergillosis. Med Mycol 53(4): 353-360, 2015.
  20. Kawakami H, Inuzuka H, Hori N, Takahashi N, Ishida K, Mochizuki K, Ohkusu K, Muraosa Y, Watanabe A, Kamei K: Inhibitory effects of antimicrobial agents against Fusarium species. Med Mycol, 53(6): 603-11, 2015.
  21. Duc PM, Thy DTM, Hatai K, Muraosa Y: Infection of striped catfish (Pangasianodon hypophthalmus) in Viet Nam caused by the fungus Fusarium incarnatum-equiseti. Bulletin of the European Association of Fish Pathologists, 35: 208-216, 2015.
  22. Fagnani R, Resende MR, Trabasso P, Mikami Y, Schreiber AZ, Lopes AFB, Muraosa Y, Kamei K, Moretti ML: Mortality related to candidemia and risk factors associated with non-Candida albicans. Infectious Diseases, 47: 930-931, 2015.
  23. Wang DN, Toyotome T, Muraosa Y, Watanabe A, Wuren T, Bunsupa S, Aoyagi K, Yamazaki M, Takino M, Kamei K: GliA in Aspergillus fumigatus is required for its tolerance to gliotoxin and affects the amount of extracellular and intracellular gliotoxin. Med Mycol, 52(5): 506-518, 2014.
  24. Wuren T, Toyotome T, Yamaguchi M, Takahashi-Nakaguchi A, Muraosa Y, Yahiro M, Wang DN, Watanabe A, Taguchi H, Kamei K: Effect of Serum Components on Biofilm Formation by Aspergillus fumigatus and Other Aspergillus Species. Jpn J Infect Dis, 67(3): 172-179, 2014.
  25. Muraosa Y, Schreiber AZ, Trabasso P, Matsuzawa T, Taguchi H, Moretti ML, Mikami Y, Kamei K: Development of cycling probe-based real-time PCR system to detect Fusarium species and Fusarium solani species complex (FSSC). Int J Med Microbiol, 304(3-4): 505-511, 2014.
  26. Kikuchi K, Watanabe A, Ito J, Oku Y, Wuren T, Taguchi H, Yarita K, Muraosa Y, Yahiro M, Yaguchi T, Kamei K: Antifungal susceptibility of Aspergillus fumigatus clinical isolates collected from various areas in Japan. J Infect Chemother, 20(5): 336-338, 2014.
  27. Kanchan C, Muraosa Y, Hatai K: Exophiala angulospora infection found in cultured Japanese flounder Paralichthys olivaceus in Japan. Bulletin of the European Association of fish Pathologists, 34(5): 187-194, 2014.
  28. Ferrari MD, Resende MR, Sakai K, Muraosa Y, Lyra L, Gonoi T, Mikami Y, Tominaga K, Kamei K, Schreiber AZ, Trabasso P, Moretti ML:Visual analysis of DNA microarray data for accurate molecular identification of non-albicans Candida isolates from patients with candidemia episodes. J Clin Microbiol, 51(11): 3826-3829, 2013.
  29. Kamei K, Watanabe A, Yaguchi T, Muraosa Y, Toyotome T, Ohno H, Miyazaki Y: Epidemiology of imported mycoses in Japan - its past and the present status. Int J Antimicrob Agents, 42, S122-S122, 2013.
  30. Muraosa Y, Sano A, and Hatai K:Molecular Identification of Marine Crustacean-pathogenic Peronosporomycetes Using DNA Sequences of ITS1 and their Pathogenicity for Nauplii of Brine Shrimps. Fish Pathology, 47 (2), 41-48, 2012.
  31. Muraosa Y, Morimoto K, Sano A, Nishimura K and Hatai K:A new peronosporomycete, Halioticida noduliformans gen. et sp. nov., isolated from white nodules in the abalone Haliotis spp. from Japan. Mycoscience, 50 (2), 106-115, 2009.
  32. Atami H, Muraosa Y, and Hatai K:Halioticida Infection Found in Wild Mantis Shrimp Oratosquilla oratoria in Japan. Fish Pathology, 44 (3), 145-150, 2009.
  33. Muraosa Y, Lawhavinit O and Hatai K:Lagenidium thermophilum isolated from eggs and larvae of black tiger shrimp Penaeus monodon in Thailand. Fish Pathology, 41(1), 35-40, 2006.