Kurihara S, Suzuki K, Yokota M, Ito T, Hayashi Y, Kikuchi R, Kageyama T, Meguro K, Tanaka S, Iwata A, Goto Y, Suto A, Nakajima H. Eosinophils Contribute to Oral Tolerance via Induction of RORγt-Positive Antigen-Presenting Cells and RORγt-Positive Regulatory T Cells. Biomolecules. 14: 89 (2024)
McCuaig B and Goto Y. Immunostimulating Commensal Bacteria and Their Potential Use as Therapeutics. Int. J. Mol. Sci. 24: 15644 (2023)
Kamioka M,Goto Y, Nakamura K, Yokoi Y, Sugimoto R, Ohira S, Kurashima Y, Umemoto S, Sato S, Kunisawa J, Takahashi Y, Domino SE, Renauld JC, Nakae S, Iwakura Y, Ernst PB, Ayabe T, Kiyono H., Nakamura K, Yokoi Y, Sugimoto R, Ohira S, Kurashima Y, Umemoto S, Sato S, Kunisawa J, Takahashi Y, Domino SE, Renauld JC, Nakae S, Iwakura Y, Ernst PB, Ayabe T, Kiyono H. Intestinal commensal microbiota and cytokines regulate Fut2+ Paneth cells for gut defense. Proc Natl Acad Sci U S A.119: e2115230119 (2022)
Dainichi T, Kabashima K, Ivanov II,Goto Y. Editorial: Regulation of Immunity by Non-Immune Cells. Front Immunol. 12:770847 (2021)
Shimizu K, Seiki I,Goto Y, Murata T. Measurement of the Intestinal pH in Mice under Various Conditions Reveals Alkalization Induced by Antibiotics. Antibiotics. 10: 180 (2021)
Yahiro K, Ogura K,Goto Y, Iyoda S, Kobayashi T, Takeuchi H, Ohnishi M, Moss J. Subtilase cytotoxin induces a novel form of Lipocalin 2, which promotes Shiga-toxigenic Escherichia coli survival.Sci Rep. 10: 18943 (2020)
Nagao-Kitamoto H, Leslie JL, Kitamoto S, Jin C, Thomsson KA, Gilliland III MG, Kuffa P,Goto Y, Jenq RR, Ishii C, Hirayama A, Seekatz AM, Martens EC, Eaton KA, Kao JY, Fukuda S, Higgins PDR, Karlsson N, Young VB, Kamada N. Interleukin-22-mediated host glycosylation prevents Clostridium difficile infection by modulating the metabolic activity of the gut microbiota. Nat Med. 26: 608-617 (2020)
Takahashi I, Hosomi K, Nagatake T, Tobou H, Yamamoto D, Hayashi I, Kurashima Y, Sato S, Shibata N,Goto Y, Maruyama F, Nakagawa I, Kuwae A, Abe A, Kunisawa J, Kiyono H. Persistent colonization of non-lymphoid tissue-resident macrophages by Stenotrophomonas maltophilia. Int Immunol. 32, 133-141 (2020)
Ichikawa T, Hirahara K, Kokubo K, Kiuchi M, Aoki A, Morimoto Y, Kumagai J, Onodera A, Mato N, Tumes D,Goto Y, Hagiwara K, Inagaki Y, Sparwasser T, Tobe K, Nakayama T. CD103hi Treg cells constrain lung fibrosis induced by CD103low tissue-resident pathogenic CD4 T cells. Nat Immunol. 20, 1469-1480 (2019)
Fujimoto K, Kawaguchi Y, Shimohigoshi M,Goto Y, Nakano Y, Usui Y, Hayashi T, Kimura Y, Uematsu M, Yamamoto T, Akeda Y, Rhee JH, Yuki Y, Ishii KJ, Crowe SE, Ernst PB, Kiyono H, Uematsu S. Antigen-specific Mucosal Immunity Regulates Development of Intestinal Bacteria-mediated Diseases. Gastroenterology. 157: 1530-1543.e4. (2019)
Goto Y. Epithelial Cells as a Transmitter of Signals From Commensal Bacteria and Host Immune Cells. Front Immunol. 10: 2057 (2019)
Saku A, Hirose K, Ito T, Iwata A, Sato T, Kaji H, Tamachi T, Suto A, Goto Y, Domino SE, Narimatsu H, Kiyono H, Nakajima H. Fucosyltransferase 2 induces lung epithelial fucosylation and exacerbates house dust mite-induced airway inflammation. J Allergy Clin Immunol. 144: 698-709.e9 (2019)
Matsuo K, Haku A, Bi B, Takahashi H, Kamada N, Yaguchi T, Saijo S, Yoneyama M, Goto Y. Fecal microbiota transplantation prevents Candida albicans from colonizing the gastrointestinal tract. Microbiol Immunol. 63:155-163 (2019)
Ito T, Hirose K, Saku A, Kono K, Takatori H, Tamachi T,Goto Y, Renauld JC, Kiyono H, Nakajima H.
J Exp Med, 214: 3037-3050 (2017)
Goto Y, Uematsu S and Kiyono H. Epithelial glycosylation in gut homeostasis and
inflammation. Nat Immunol, 17: 1244-1251 (2016)
Goto Y, Lamichhane A, Kamioka M, Sato S, Honda K, Kunisawa J and Kiyono H. IL-10-producing CD4+ T cells negatively regulate fucosylation of epithelial cells in the gut. Sci Rep, 5: 15918 (2015)
Panea C, Farkas AM, Goto Y, Abdollahi-Roodsaz S, Lee C, Koscso B, Gowda K, Hohl TM, Bogunovic M and Ivanov II. Intestinal Monocyte-Derived Macrophages Control Commensal-Specific Th17 Responses. Cell Rep, 12: 1314-1324 (2015)
Goto Y, Kurashima Y, Kiyono H. The gut microbiota and inflammatory bowel disease. Curr Opin Rheumatol, 27: 388-396 (2015)
Farkas AM*, Panea C*, Goto Y*, Nakato G, Galan-Diez M, Narushima S, Honda K, Ivanov II. Colonization and induction of Th17 cells by segmented filamentous bacteria in the murine intestine. J Immunol Methods, 421: 104-111 (2015) *equally contribution
Goto Y, Obata T, Kunisawa J, Sato S, Ivanov II, Lamichhane A, Takeyama N, Kamioka M, Sakamoto M, Matsuki T, Setoyama H, Imaoka A, Uematsu S, Akira S, Domino SE, Kulig P, Becher B, Renauld JC, Sasakawa C, Umesaki Y, Benno Y, Kiyono H. Innate lymphoid cells regulate intestinal epithelial fucosylation. Science, 345: 1254009 (2014)
Goto Y, Panea C, Nakato G, Cebula A, Lee C, Diez MG, Laufer TM, Ignatowicz L, Ivanov II. Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation.Immunity, 40: 594-607 (2014).
Kurashima Y, Goto Y, Kiyono H. Mucosal innate immune cells regulate both gut homeostasis and intestinal inflammation. Eur J Immunol, 43: 3108-3115 (2013).
Obata T, Shibata N, Goto Y, Ishikawa I, Sato S, Kunisawa J, Kiyono H. Critical role of dendritic cells in T cell retention in the interfollicular region of Peyer's patches. J Immunol, 191: 942-948 (2013).
Kunisawa J, Gohda M, Hashimoto E, Ishikawa I, Higuchi M, Suzuki Y, Goto Y, Panea C, Ivanov II, Sumiya R, Aayam L, Wake T, Tajiri S, Kurashima Y, Shikata S, Akira S, Takeda K, Kiyono H. Microbe-dependent CD11b+ IgA+ plasma cells mediate robust early-phase intestinal IgA responses in mice. Nat Commun, 4: 1772 (2013).
Kusu T, Kayama H, Kinoshita M, Jeon SG, Ueda Y, Goto Y, Okumura R, Saiga H, Kurakawa T, Ikeda K, Maeda Y, Nishimura J, Arima Y, Atarashi K, Honda K, Murakami M, Kunisawa J, Kiyono H, Okumura M, Yamamoto M, Takeda K. Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine. J Immunol, 190: 774-783 (2013).
Goto Y, Ivanov II. Intestinal epithelial cells as mediators of the commensal-host immune crosstalk. Immunol Cell Biol, 91: 204-214 (2013).
Shibata T, Takemura N, Motoi Y, Goto Y, Karuppuchamy T, Izawa K, Li X, Akashi-Takamura S, Tanimura N, Kunisawa J, Kiyono H, Akira S, Kitamura T, Kitaura J, Uematsu S, Miyake K. PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells. Int Immunol, 24: 613-623 (2012).
GotoY, Kiyono H. Epithelial barrier: an interface for the cross-communication between gut flora and immune system. Immunol Rev, 245: 147-163 (2012).
Ogawa M, Yoshikawa Y, Kobayashi T, Mimuro H, Fukumatsu M, Kiga K, Piao Z, Ashida H, Yoshida M, Kakuta S, Koyama T, GotoY, Nagatake T, Nagai S, Kiyono H, Kawalec M, Reichhart JM, Sasakawa C. A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens. Cell Host and Microbe, 19: 376-389 (2011).
Goto Y, Kiyono H. Epithelial cell microRNAs in gut immunity. Nat Immunol, 12:195-197, (2011)
Terahara K, Nochi T, Yoshida M, Takahashi Y, GotoY, Hatai H, Kurokawa S, Jang MH, Kweon MN, Domino SE, Hiroi T, Yuki Y, Tsunetsugu-Yokota Y, Kobayashi K, Kiyono H. Distinct fucosylation of M cells and epithelial cells by Fut1 and Fut2, respectively, in response to intestinal environmental stress. Biochem Biophys Res Commun, 404: 822-828 (2011).
Obata T, Goto Y, Kunisawa J, Sato S, Sakamoto M, Setoyama H, Matsuki T, Nonaka K, Shibata N, Gohda M, Kagiyama Y, Nochi T, Yuki Y, Fukuyama Y, Mukai A, Shinzaki S, Fujihashi K, Sasakawa C, Iijima H, Goto M, Umesaki Y, Benno Y, Kiyono H. Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosalantibody-mediated symbiosis. Proc Natl Acad Sci U S A, 107: 7419-7424 (2010).
Imada M, Masuda K, Satoh R, Ito Y, Goto Y, Matsuoka T, Endo S, Nakamura A, Kawamoto H, Takai T. Ectopically expressed PIR-B on T cells constitutively binds to MHC class I and attenuates T helper type 1 responses. Int Immunol, 21: 1151-1161 (2009).
Terahara K, Yoshida M, Taguchi F, Igarashi O, Nochi T, Gotoh Y, Yamamoto T, Tsunetsugu-Yokota Y, Beauchemin N, Kiyono H. Expression of newly identified secretory CEACAM1(a) isoforms in the intestinal epithelium. Biochem Biophys Res Commun, 383: 340-346 (2009).
Kobayashi T, Takahashi K, Nagai Y, Shibata T, Otani M, Izui S, Akira S, Gotoh Y, Kiyono H, Miyake K. Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/lpr mice. Int Immunol, 20: 881-891 (2008).
