Publications

2023 |2022 |2021 |2020 |2019 |2018 |2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2002 | 2001 | ~2000

2024

  • Yoneyama M, Kato H, Fujita T: Physiological functions of RIG-I like receptors. Immunity, 57(4): 731-751, 2024.Link
  • Shibata K, Moriizumi H, Onomoto K, Kaneko Y, Miyakawa T, Zenno S, Tanokura M, Yoneyama M, Takahashi T, Ui-Tei K: Caspase-mediated processing of TRBP regulates apoptosis during viral infection. Nucleic Acids Res, gkae246, 2024.Link

2023

  • Im JH, Duic I, Yoshimizu SH, Onomoto K, Yoneyama M, Kato H, Fujita T: Mechanisms of length-dependent recognition of viral double-stranded RNA by RIG-I. Sci Rep, 13(1): 6318, 2023.Link

2022

  • Kojima I, Onomoto K, Zuo WJ, Ozawa M, Okuya K, Naitou K, Izumi F, Okajima M, Fujiwara T, Ito N, Yoneyama M, Yamada K, Nishizono A, Sugiyama M, Fujita T, Masatani T: Amino acid at position 95 in matrix protein of rabies virus is involved in antiviral stress granule formation in infected cells. J Virol, 96: e0081022, 2022.Link
  • Iwasawa M, Miyachi H, Wakabayashi S, Sugihira T, Aoyama R, Nakagawa S, Katayama Y, Yoneyama M, Hara H, Iwakura Y, Matsumoto M, Inohara N, Koguchi-Yoshioka H, Fujimoto M, Núñez G, Matsue H, Nakamura Y, Saijo S: Epidermal clearance of Candida albicans is mediated by IL-17 but independent of fungal innate immune receptors. Int Immunol, 34: 409-420, 2022.Link
  • Onomoto K, Yoneyama M, Asakura S, Matsumoto S, Kaiho T: Inactivation effects of iodine on SARS-CoV-2.(Japanese) J Antibacterial Antifungal Agents, 50(3): 97-103, 2022.

2021

  • Hayashi Y, Suzuki H, Nakajima W, Uehara I, Tanimura A, Himeda T, Koike S, Katsuno T, Kitajiri S, Koyanagi N, Kawaguchi Y, Onomoto K, Kato H, Yoneyama M, Fujita T, Tanaka N: Virus-infection in cochlear supporting cells induces audiosensory receptor hair cell death by TRAIL-induced necroptosis. PLoS One, 16: e026044318, 2021.Link
  • Onomoto K, Onoguchi K, Yoneyama M: Regulation of RIG-I-like receptor-mediated signaling: Interaction between host and viral factors. Cell Mol Immunol, 18: 539–555,2021.Link

2020

  • Hayashi Y, Suzuki H, Nakajima W, Uehara I, Tanimura A, Himeda T, Koike S, Katsuno T, Kitajiri SI, Koyanagi N, Kawaguchi Y, Onomoto K, Kato H, Yoneyama M, Fujita T, Tanaka N: Cochlear supporting cells function as macrophage-like cells and protect audiosensory receptor hair cells from pathogens. Sci Rep, 10: 6740, 2020.Link
  • Takahashi T, Nakano Y, Onomoto K, Yoneyama M, Ui-Tei K: LGP2 virus sensor enhances apoptosis by upregulating apoptosis regulatory genes through TRBP-bound miRNAs during viral infection. Nucleic Acids Res,48: 1494-1507, 2020.Link

2019

  • Takahasi K, Onomoto K, Horiuchi M, Kato H, Fujita T, Yoneyama M: Identification of a new autoinhibitory domain of interferon-beta promoter stimulator-1 (IPS-1) for the tight regulation of oligomerization-driven signal activation. Biochem Biophys Res Commun, 517: 662-669, 2019.Link
  • Matsuo K, Haku A, Bi B, Takahashi H, Kamada N, Yaguchi T, Saijo S, Yoneyama M, Goto Y: Fecal microbiota transplantation prevents Candida albicans from colonizing the gastrointestinal tract. Microbiol Immunol, 63: 155-163, 2019.Link
  • Ohto T, Konishi M, Tanaka H, Onomoto K, Yoneyama M, Nakai Y, Tange K, Yoshioka H, Akita H: Inhibition of the Inflammatory Pathway Enhances Both the in Vitro and in Vivo Transfection Activity of Exogenous in Vitro-Transcribed mRNAs Delivered by Lipid Nanoparticles. Biol Pharm Bull, 42: 299-302, 2019.Link

2018

  • Takahashi T, Nakano Y, Onomoto K,Yoneyama M, Ui-Tei K: Virus Sensor RIG-I Represses RNA Interference by Interacting with TRBP through LGP2 in Mammalian Cells. Genes, 9: E511, 2018.Link
  • Takahashi T, Nakano Y, Onomoto K, Murakami F, Komori C, Suzuki Y, Yoneyama M, Ui-Tei K: LGP2 virus sensor regulates gene expression network mediated by TRBP-bound microRNAs. Nucleic Acids Res,46: 9134-9147, 2018.Link

2016

  • Oh SW, Onomoto K, Wakimoto M, Onoguchi K, Ishidate F, Fujiwara T, Yoneyama M, Kato H, Fujita T: Leader-containing uncapped viral transcript activates RIG-I in antiviral stress granules. PLoS Pathog, 12: e1005444, 2016.Link
  • Yoneyama M, Jogi M, Onomoto K: Regulation of antiviral innate immune signaling by stress-induced RNA granules. J Biochem,159: 279-286, 2016.Link

2015

  • Iijima S, Matsuura K, Watanabe T, Onomoto K, Fujita T, Ito K, Iio E, Miyaki T, Fujiwara K, Shinkai N, Kusakabe A, Endo M, Nojiri S, Joh T, Tanaka Y: Influence of genes suppressing interferon effects in peripheral blood mononuclear cells during triple antiviral therapy for chronic hepatitis C. PLoS One, 10: e0118000, 2015.Link
  • Okazaki T, Higuchi M, Takeda K, Iwatsuki-Horimoto K, Kiso M, Miyagishi M, Yanai H, Kato A, Yoneyama M, Fujita T, Taniguchi T, Kawaoka Y, Ichijo H, Gotoh Y: The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response. Sci Signal, 8: ra78, 2015.Link
  • Yoneyama M, Onomoto K, Jogi M, Akaboshi T, Fujita T: Viral RNA detection by RIG-I-like receptors. Curr Opin Immunol, 32: 48-53, 2015.Link

2014

  • Narita R, Takahasi K, Murakami E, Hirano E, Yamamoto SP, Yoneyama M, Kato H, Fujita T: A novel function of human Pumilio proteins in cytoplasmic sensing of viral infection. PLoS Pathog, 10: e1004417, 2014.Link
  • Onomoto K, Yoneyama M, Fung G, Kato H, Fujita T: Antiviral innate immunity and stress granule responses.Trends Immunol, 35: 420-428, 2014.Link
  • Yonekawa A, Saijo S, Hoshino Y, Miyake Y, Ishikawa E, Suzukawa M, Inoue H, Tanaka M, Yoneyama M, Oh-hora M, Akashi K, and Yamasaki S: Dectin-2 Is a Direct Receptor for Mannose-Capped Lipoarabinomannan of Mycobacteria. Immunity 41: 402-413, 2014.Link
  • Yoo JS, Takahasi K, Ng CS, Ouda R, Onomoto K, Yoneyama M, Lai JC, Lattmann S, Nagamine Y, Matsui T, Iwabuchi K, Kato H, Fujita T: DHX36 Enhances RIG-I Signaling by Facilitating PKR-Mediated Antiviral Stress Granule Formation. PLoS Pathog, 10: e1004012, 2014.Link

2013

  • Ng CS, Jogi M, Yoo JS, Onomoto K, Koike S, Iwasaki T, Yoneyama M, Kato H, Fujita T: EMCV disrupts stress granules, the critical platform for triggering antiviral innate immune responses. J Virol, 87: 9511-22, 2013.Link
  • Hayashi Y, Onomoto K, Narita R, Yoneyama M, Kato H, Nakagawa T, Ito J, Taura A, Fujita T: Virus-induced expression of retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5 in the cochlear sensory epithelium. Micorbes infect, 15: 592-8, 2013.Link
  • Takamatsu S, Onoguchi K, Onomoto K, Narita R, Takahasi K, Ishidate F, Fujiwara TK, Yoneyama M, Kato H, Fujita T: Functional characterization of domains of IPS-1 using an inducible oligomerization system. PLoS One, 8: e53578, 2013.Link
  • Sekai M, Tani-ichi S, Yoneyama M, Fujita T, Kina T, Ikuta K: Lymphocyte-stromal cell interaction induces IL-7 expression by interferon regulatory factors. Mol Immunol, 54: 378-385, 2013.Link
  • Oarada M, Miki T, Kohno S, Sakai K, Nikawa T, Yoneyama M, Gonoi T: Refeeding with a standard diet after a 48 hour fast elicits an inflammatory response in the mouse liver. J Nutr Biochem, 24: 1314-23, 2013.Link
  • Nitta S, Sakamoto N, Nakagawa M, Kakinuma S, Mishima K, Kusano-Kitazume A, Kiyohashi K, Murakawa M, Nishimura-Sakurai Y, Azuma S, Tasaka-Fujita M, Asahina Y, Yoneyama M, Fujita T, Watanabe M: Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type-I interferon-dependent innate immunity.Hepatology, 57: 46-58, 2013.Link

2012

  • Inoue K, Tsukiyama-Kohara K, Matusda C, Yoneyama M, Fujita T, Kuge S, Yoshida M, Kohara M: Impairment of interferon regulatory factor-3 activation by hepatitis C virus core protein basic amino acid region 1. Biochem Biophys Res Commun, 428: 494-499, 2012.Link
  • Xing F, Matsumiya T, Onomoto K, Hayakari R, Imaizumi T, Yoshida H, Yoneyama M, Fujita T, Satoh K: Foreign RNA induces the degradation of mitochondrial antiviral signaling protein (MAVS): the role of intracellular antiviral factors. PLoS One, 7: e45136, 2012.Link
  • Marumoto S, Yamamoto SP, Nishimura H, Onomoto K, Yatagai M, Yazaki K, Fujita T, Watanabe T: Identification of germicidal compound against picornavirus in bamboo pyroligneous acid. J Agric Food Chem, 60: 9106-11, 2012.Link
  • Onomoto K, Jogi M, Yoo J-S, Narita R, Morimoto S, Takemura A, Sambhara S, Kawaguchi A, Osari S, Nagata K, Matsumiya T, Namiki H, Yoneyama M, Fujita T: Critical Role of an Antiviral Stress Granule Containing RIG-I and PKR in Viral Detection and Innate Immunity. PLoS One, 7: e430331, 2012.Link

2011

  • Onomoto K, Morimoto S, Kawaguchi T, Toyoda H, Tanaka M, Kuroda M, Uno K, Kumada T, Matsuda F, Shimotohno K, Fujita T, Murakami Y: Dysregulation of IFN system can lead to poor response to pegylated interferon and ribavirin therapy in chronic hepatitis C. PLoS One, 6: e19799, 2011.Link
  • Kageyama M, Takahasi K, Narita R, Hirai R, Yoneyama M, Kato H, Fujita T: 55 amino acid linker between helicase and carboxyl terminal domains of RIG-I functions as a critical repression domain and determines inter-domain conformation. Biochem Biophys Res Commun>, 415: 75-81, 2011.Link
  • Ouda R, Onomoto K, Takahasi K, Edwards MR, Kato H, Yoneyama M, Fujita T: Retinoic Acid-inducible Gene I-inducible miR-23b Inhibits Infections by Minor Group Rhinoviruses through Down-regulation of the Very Low Density Lipoprotein Receptor. J Biol Chem, 286: 26210-26219, 2011.Link
  • Onoguchi K, Yoneyama M, Fujita T: Retinoic Acid-inducible gene-I-like receptors. J Interferon Cytokine Res, 31: 27-31, 2011.Link

2010

  • Onoguchi K, Onomoto K, Takamatsu S, Jogi M, Takemura A, Morimoto S, Julkunen I, Namiki H, Yoneyama M, Fujita T: Virus-infection or 5'ppp-RNA activates antiviral signal through redistribution of IPS-1 mediated by MFN1.PLoS Pathog, 6: e1001012, 2010.Link
  • Takahasi K, Horiuchi M, Fujii K, Nakamura S, Noda NN, Yoneyama M, Fujita T, Inagaki F: Ser386 phosphorylation of transcription factor IRF-3 induces dimerization and association with CBP/p300 without overall conformational change. Genes Cells, 15: 901-910, 2010.Link
  • Satoh T, Kato H, Kumagai Y, Yoneyama M, Sato S, Matsushita K, Tsujimura T, Fujita T, Akira S, Takeuchi O: LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses. Proc Natl Acad Sci USA, 107: 1512-7, 2010.Link
  • Yoneyama M, Fujita T: Recognition of viral nucleic acids in innate immunity. Rev Med Virol, 20: 4-22, 2010.Link

2009

  • Takahasi K, Kumeta H,Tsuduki N, Narita R, Hirai R, Yoneyama M, Horiuhci M, Ogura K, Fujita T, Inagaki F: Solition structure of cytosolic RNA sensor MDA5 and LGP2 C-terminal domain: identification of the RNA recognition loop in RIG-I-like receptors. J Biol Chem, 284: 17465-17474, 2009.Link
  • Yoneyama M, Fujita T: RNA recognition and signal transduction by RIG-I-like receptors. Immunol Rev, 227: 54-65, 2009.Link
  • Shigemoto T, Kageyama M, Hirai R, Zheng J, Yoneyama M, Fujita T: Identification of loss of function mutations in human genes encoding RIG-I and MDA5: implications for resistance to type I diabetes. J Biol Chem, 284: 13348-13354, 2009.Link

2008

  • Yoneyama M, Fujita T: Structural mechanism of RNA recognition by RIG-I-like receptors. Immunity, 29: 178-81, 2008.Link
  • Yoneyama M, Onomoto K, Fujita T: Cytoplasmic recognition of RNA. Adv Drug Deliv Rev, 60: 841-846, 2008.Link
  • Takahasi K, Yoneyama M(equal contribution), Nishihori T, Hirai R, Kumeta H, Narita R, Gale M Jr, Inagaki F, Fujita T: Non-self RNA-Sensing Mechanism of RIG-I Helicase and Activation of Antiviral Immune Responses. Mol Cell, 29: 428-440, 2008.Link

2007

  • Onomoto K, Yoneyama M, Fujita T: Regulation of antiviral innate immune responses by RIG-I family of RNA helicases. Curr Top Microbiol Immunol, 316: 193-205, 2007.Link
  • Yoneyama M, Fujita T: Cytoplasmic double-stranded DNA sensor. Nat Immunol, 8: 907-908, 2007.Link
  • Yoneyama M, Fujita T: RIG-I family RNA helicases: Cytoplasmic sensor for antiviral innate immunity. Cytokine Growth Factor Rev, 18: 545-51, 2007.Link
  • Yoneyama M, Fujita T: Function of RIG-I-like Receptors in Antiviral Innate Immunity. J Biol Chem, 282: 15315-15318, 2007.Link
  • Fujita T, Onoguchi K, Onomoto K, Hirai R, Yoneyama M: Triggering antiviral response by RIG-I-related RNA helicases. Biochimie, 89: 754-60, 2007.Link
  • Tasaka M, Sakamoto N, Itakura Y, Nakagawa M, Itsui Y, Sekine-Osajima Y, Nishimura-Sakurai Y, Chen CH, Yoneyama M, Fujita T, Wakita T, Maekawa S, Enomoto N, Watanabe M: Hepatitis C virus non-structural proteins responsible for suppression of the RIG-I/Cardif-induced interferon response. J Gen Virol, 88: 3323-33, 2007.Link
  • Onoguchi K, Yoneyama M, Takemura A, Akira S, Taniguchi T, Namiki H, Fujita T: Virus infections activate type I and type III interferon genes through a common mechanism. J Biol Chem, 282: 7576-81, 2007.Link

2006

  • Sasai M, Shingai M, Funami K, Yoneyama M, Fujita T, Matsumoto M, Seya, T: NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction. J Immunol, 177: 8676-83, 2006.Link
  • Yoshikawa T, Iwasaki T, Ida-Hosonuma M, Yoneyama M, Fujita T, Horie H, Miyazawa M, Abe S, Simizu B, Koike S: Role of the alpha/beta interferon response in the acquisition of susceptibility to poliovirus by kidney cells in culture. J Virol, 80: 4313-25, 2006.Link
  • Kato H, Takeuchi O, Sato S, Yoneyama M, Yamamoto M, Matsui K, Uematsu S, Jung A, Kawai T, Ishii KJ, Yamaguchi O, Otsu K, Tsujimura T, Koh CS, Reis e Sousa C, Matsuura Y, Fujita T, Akira S: Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature, 441: 101-105, 2006.Link
  • Loo YM, Owen DM, Li K, Erickson AK, Johnson CL, Fish PM, Carney DS, Wang T, Ishida H, Yoneyama M, Fujita T, Saito T, Lee WM, Hagedorn CH, Lau DT, Weinman SA, Lemon SM, Gale M Jr: Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection. Proc Natl Acad Sci USA, 103: 6001-06, 2006.Link

2005

  • Fujita T, Yoneyama M: Innate immune receptors and IRF family transcription factor. Curr Med Chem-Anti-Inflammatory & Anti-Allergy Agents, 4: 29-33, 2005.Link
  • Kato H, Sato S, Yoneyama M, Yamamoto M, Uematsu S, Matsui K, Tsujimura T, Takeda K, Fujita T, Takeuchi O, Akira S: Cell Type-Specific Involvement of RIG-I in Antiviral Response. Immunity, 23: 19-28, 2005.Link
  • Yoneyama M, Kikuchi M, Matsumoto K, Imaizumi T, Miyagishi M, Taira K, Foy E, Loo YM, Gale M Jr, Akira S, Yonehara S, Kato A, Fujita T: Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol, 175: 2851-58, 2005.Link
  • Breiman A, Grandvaux N, Lin R, Ottone C, Akira S, Yoneyama M, Fujita T, Hiscott J, Meurs EF: Inhibition of RIG-I-Dependent Signaling to the Interferon Pathway during Hepatitis C Virus Expression and Restoration of Signaling by IKKe. J Virol, 79: 3969-78, 2005.Link
  • Ida-Hosonuma M, Iwasaki T, Yoshikawa T, Nagata N, Sato Y, Sata T, Yoneyama M, Fujita T, Taya C, Yonekawa H, Koike S: The Alpha/Beta Interferon Response Controls Tissue Tropism and Pathogenicity of Poliovirus. J Virol, 79: 4460-69, 2005.Link
  • Foy E, Li K, Sumpter R Jr, Loo YM, Johnson CL, Wang C, Fish PM, Yoneyama M, Fujita T, Lemon SM, Gale M Jr: Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling. Proc Natl Acad Sci USA, 102: 2986-91, 2005.Link
  • Sumpter R Jr, Loo YM, Foy E, Li K, Yoneyama M, Fujita T, Lemon SM, Gale M Jr: Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I. J Virol, 79: 2689-99, 2005.Link

2004

  • Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T: The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol, 5: 730-737, 2004.Link
  • Mori M, Yoneyama M, Ito T, Takahashi K, Inagaki F, Fujita T: Identification of Ser-386 of interferon regulatory factor 3 as critical target for inducible phosphorylation that determines activation. J Biol Chem, 279: 9698-702, 2004.Link

2002

  • Suhara W, Yoneyama M, Kitabayashi I, Fujita T: Direct involvement of CREB-binding protein/p300 in sequence-specific DNA binding of virus-activated interferon regulatory factor-3 holocomplex. J Biol Chem, 277: 22304-2231, 2002.Link
  • Yoneyama M, Suhara W, Fujita T: Control of IRF-3 activation by Phosphorylation. J Interferon Cytokine Res, 22: 73-76, 2002.Link
  • Shinobu N, Iwamura T, Yoneyama M, Yamaguchi K, Suhara W, Fukuhara Y, Amano F, Fujita T: Involvement of TIRAP/MAL in signaling for the activation of interferon regulatory factor 3 by lipopolysaccharide. FEBS Lett, 517: 251-256, 2002.Link

2001

  • Iwamura T, Yoneyama M, Yamaguchi K, Suhara W, Mori W, Shiota K, Okabe Y, Namiki H, Fujita T: Induction of IRF-3/-7 kinase and NF-kB in response to double-stranded RNA and virus infection: common and unique pathways. Genes Cells, 6: 375-388, 2001.Link
  • Iwamura T, Yoneyama M, Koizumi N, Okabe Y, Namiki H, Samuel CE, Fujita T: PACT, a double-stranded RNA binding protein acts as a positive regulator for type I interferon gene induced by Newcastle Desease Virus.Biochem Biophys Res Commun, 282: 515-523, 2001.Link

~2000

  • Suhara W, Yoneyama M, Iwamura T, Yoshimura S, Tamura K, Namiki H, Aimoto S, Fujita T: Analysis of virus-induced homomeric and heteromeric protein associations between IRF-3 and coactivator CBP/p300. J Biochem, 128: 301-307, 2000.Link
  • Yoneyama M, Suhara W, Fukuhara Y, Fukuda M, Nishida E, Fujita T: Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300. EMBO J, 17: 1087-95, 1998.Link
  • Yoneyama M, Suhara W, Fukuhara Y, Sato M, Ozato K, Fujita T: Autocrine amplification of type I interferon gene expression mediated by interferon stimulated gene factor 3 (ISGF3). J Biochem, 120: 160-190, 1996.Link
  • Suhara W, Yoneyama M, Yonekawa H, Fujita T: Structure of mouse interferon stimulated gene factor 3g (ISGF3g/p48) cDNA and chromosomal localization of the gene. J Biochem, 119: 231-234, 1996.Link
  • Shibuya H, Yoneyama M(equal contribution), Ninomiya-Tsuji J, Matsumoto K, Taniguchi T: IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: demonstration of a novel role for c-myc.Cell, 70: 57-67, 1992.Link
  • Shibuya H, Yoenyama M, Nakamura Y, Harada H, Hatakeyama M, Minamoto S, Kono T, Doi T, White R, Taniguchi T: The human interleukin-2 receptor beta-chain gene: genomic organization, promoter analysis and chromosomal assignment. Nucleic Acids Res, 18: 3697-703, 1990.Link
  • Shibuya H, Yoneyama M, Taniguchi T: Involvement of a common transcription factor in the regulated expression of IL-2 and IL-2 receptor genes. Int Immunol, 1: 43-49,1989.Link