<2016>

Oh SW, Onomoto K, Wakimoto M, Onoguchi K, Ishidate F, Fujiwara T, Yoneyama M, Kato H, Fujita T: Leader-containing uncapped viral transcript activates RIG-I in antiviral stress granules. PLoS Pathog, 12: e1005444, 2016.Link

Yoneyama M, Jogi M, Onomoto K: Regulation of antiviral innate immune signaling by stress-induced RNA granules. J Biochem,159: 279-286, 2016.Link

<2015>

Iijima S, Matsuura K, Watanabe T, Onomoto K, Fujita T, Ito K, Iio E, Miyaki T, Fujiwara K, Shinkai N, Kusakabe A, Endo M, Nojiri S, Joh T, Tanaka Y: Influence of genes suppressing interferon effects in peripheral blood mononuclear cells during triple antiviral therapy for chronic hepatitis C. PLoS One, 10: e0118000, 2015.Link

Okazaki T, Higuchi M, Takeda K, Iwatsuki-Horimoto K, Kiso M, Miyagishi M, Yanai H, Kato A, Yoneyama M, Fujita T, Taniguchi T, Kawaoka Y, Ichijo H, Gotoh Y: The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response. Sci Signal, 8: ra78, 2015.Link

Yoneyama M, Onomoto K, Jogi M, Akaboshi T, Fujita T: Viral RNA detection by RIG-I-like receptors. Curr Opin Immunol, 32: 48-53, 2015.Link

<2014>

Narita R, Takahasi K, Murakami E, Hirano E, Yamamoto SP, Yoneyama M, Kato H, Fujita T: A novel function of human Pumilio proteins in cytoplasmic sensing of viral infection. PLoS Pathog, 10: e1004417, 2014.Link

Onomoto K, Yoneyama M, Fung G, Kato H, Fujita T: Antiviral innate immunity and stress granule responses. Trends Immunol, 35: 420-428, 2014.Link

Yonekawa A, Saijo S, Hoshino Y, Miyake Y, Ishikawa E, Suzukawa M, Inoue H, Tanaka M, Yoneyama M, Oh-hora M, Akashi K, and Yamasaki S: Dectin-2 Is a Direct Receptor for Mannose-Capped Lipoarabinomannan of Mycobacteria. Immunity 41: 402-413, 2014.Link

Yoo JS, Takahasi K, Ng CS, Ouda R, Onomoto K, Yoneyama M, Lai JC, Lattmann S, Nagamine Y, Matsui T, Iwabuchi K, Kato H, Fujita T: DHX36 Enhances RIG-I Signaling by Facilitating PKR-Mediated Antiviral Stress Granule Formation. PLoS Pathog, 10: e1004012, 2014.Link

<2013>

Ng CS, Jogi M, Yoo JS, Onomoto K, Koike S, Iwasaki T, Yoneyama M, Kato H, Fujita T: EMCV disrupts stress granules, the critical platform for triggering antiviral innate immune responses. J Virol, 87: 9511-22, 2013.Link

Hayashi Y, Onomoto K, Narita R, Yoneyama M, Kato H, Nakagawa T, Ito J, Taura A, Fujita T: Virus-induced expression of retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5 in the cochlear sensory epithelium. Micorbes infect, 15: 592-8, 2013.Link

Takamatsu S, Onoguchi K, Onomoto K, Narita R, Takahasi K, Ishidate F, Fujiwara TK, Yoneyama M, Kato H, Fujita T: Functional characterization of domains of IPS-1 using an inducible oligomerization system. PLoS One, 8: e53578, 2013.Link

Sekai M, Tani-ichi S, Yoneyama M, Fujita T, Kina T, Ikuta K: Lymphocyte-stromal cell interaction induces IL-7 expression by interferon regulatory factors. Mol Immunol, 54: 378-385, 2013.Link

Oarada M, Miki T, Kohno S, Sakai K, Nikawa T, Yoneyama M, Gonoi T: Refeeding with a standard diet after a 48 hour fast elicits an inflammatory response in the mouse liver. J Nutr Biochem, 24: 1314-23, 2013.Link

Nitta S, Sakamoto N, Nakagawa M, Kakinuma S, Mishima K, Kusano-Kitazume A, Kiyohashi K, Murakawa M, Nishimura-Sakurai Y, Azuma S, Tasaka-Fujita M, Asahina Y, Yoneyama M, Fujita T, Watanabe M: Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type-I interferon-dependent innate immunity. Hepatology, 57: 46-58, 2013.Link

<2012>

Inoue K, Tsukiyama-Kohara K, Matusda C, Yoneyama M, Fujita T, Kuge S, Yoshida M, Kohara M: Impairment of interferon regulatory factor-3 activation by hepatitis C virus core protein basic amino acid region 1. Biochem Biophys Res Commun, 428: 494-499, 2012.Link

Xing F, Matsumiya T, Onomoto K, Hayakari R, Imaizumi T, Yoshida H, Yoneyama M, Fujita T, Satoh K: Foreign RNA induces the degradation of mitochondrial antiviral signaling protein (MAVS): the role of intracellular antiviral factors. PLoS One, 7: e45136, 2012.Link

Marumoto S, Yamamoto SP, Nishimura H, Onomoto K, Yatagai M, Yazaki K, Fujita T, Watanabe T: Identification of germicidal compound against picornavirus in bamboo pyroligneous acid. J Agric Food Chem, 60: 9106-11, 2012.Link

Onomoto K, Jogi M, Yoo J-S, Narita R, Morimoto S, Takemura A, Sambhara S, Kawaguchi A, Osari S, Nagata K, Matsumiya T, Namiki H, Yoneyama M, Fujita T: Critical Role of an Antiviral Stress Granule Containing RIG-I and PKR in Viral Detection and Innate Immunity. PLoS One, 7: e430331, 2012.Link

<2011>

Onomoto K, Morimoto S, Kawaguchi T, Toyoda H, Tanaka M, Kuroda M, Uno K, Kumada T, Matsuda F, Shimotohno K, Fujita T, Murakami Y: Dysregulation of IFN system can lead to poor response to pegylated interferon and ribavirin therapy in chronic hepatitis C. PLoS One, 6: e19799, 2011.Link

Kageyama M, Takahasi K, Narita R, Hirai R, Yoneyama M, Kato H, Fujita T: 55 amino acid linker between helicase and carboxyl terminal domains of RIG-I functions as a critical repression domain and determines inter-domain conformation. Biochem Biophys Res Commun>, 415: 75-81, 2011.Link

Ouda R, Onomoto K, Takahasi K, Edwards MR, Kato H, Yoneyama M, Fujita T: Retinoic Acid-inducible Gene I-inducible miR-23b Inhibits Infections by Minor Group Rhinoviruses through Down-regulation of the Very Low Density Lipoprotein Receptor. J Biol Chem, 286: 26210-26219, 2011.Link

Onoguchi K, Yoneyama M, Fujita T: Retinoic Acid-inducible gene-I-like receptors. J Interferon Cytokine Res, 31: 27-31, 2011.Link

<2010>

Onoguchi K, Onomoto K, Takamatsu S, Jogi M, Takemura A, Morimoto S, Julkunen I, Namiki H, Yoneyama M, Fujita T: Virus-infection or 5'ppp-RNA activates antiviral signal through redistribution of IPS-1 mediated by MFN1. PLoS Pathog, 6: e1001012, 2010.Link

Takahasi K, Horiuchi M, Fujii K, Nakamura S, Noda NN, Yoneyama M, Fujita T, Inagaki F: Ser386 phosphorylation of transcription factor IRF-3 induces dimerization and association with CBP/p300 without overall conformational change. Genes Cells, 15: 901-910, 2010.Link

Satoh T, Kato H, Kumagai Y, Yoneyama M, Sato S, Matsushita K, Tsujimura T, Fujita T, Akira S, Takeuchi O: LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses. Proc Natl Acad Sci USA, 107: 1512-7, 2010.Link

Yoneyama M, Fujita T: Recognition of viral nucleic acids in innate immunity. Rev Med Virol, 20: 4-22, 2010.Link

<2009>

Takahasi K, Kumeta H,Tsuduki N, Narita R, Hirai R, Yoneyama M, Horiuhci M, Ogura K, Fujita T, Inagaki F: Solition structure of cytosolic RNA sensor MDA5 and LGP2 C-terminal domain: identification of the RNA recognition loop in RIG-I-like receptors. J Biol Chem, 284: 17465-17474, 2009.Link

Yoneyama M, Fujita T: RNA recognition and signal transduction by RIG-I-like receptors. Immunol Rev, 227: 54-65, 2009.Link

Shigemoto T, Kageyama M, Hirai R, Zheng J, Yoneyama M, Fujita T: Identification of loss of function mutations in human genes encoding RIG-I and MDA5: implications for resistance to type I diabetes. J Biol Chem, 284: 13348-13354, 2009.Link

<2008>

Yoneyama M, Fujita T: Structural mechanism of RNA recognition by RIG-I-like receptors. Immunity, 29: 178-81, 2008.Link

Yoneyama M, Onomoto K, Fujita T: Cytoplasmic recognition of RNA. Adv Drug Deliv Rev, 60: 841-846, 2008.Link

Takahasi K, Yoneyama M(equal contribution), Nishihori T, Hirai R, Kumeta H, Narita R, Gale M Jr, Inagaki F, Fujita T: Non-self RNA-Sensing Mechanism of RIG-I Helicase and Activation of Antiviral Immune Responses. Mol Cell, 29: 428-440, 2008.Link

<2007>

Onomoto K, Yoneyama M, Fujita T: Regulation of antiviral innate immune responses by RIG-I family of RNA helicases. Curr Top Microbiol Immunol, 316: 193-205, 2007.Link

Yoneyama M, Fujita T: Cytoplasmic double-stranded DNA sensor. Nat Immunol, 8: 907-908, 2007.Link

Yoneyama M, Fujita T: RIG-I family RNA helicases: Cytoplasmic sensor for antiviral innate immunity. Cytokine Growth Factor Rev, 18: 545-51, 2007.Link

Yoneyama M, Fujita T: Function of RIG-I-like Receptors in Antiviral Innate Immunity. J Biol Chem, 282: 15315-15318, 2007.Link

Fujita T, Onoguchi K, Onomoto K, Hirai R, Yoneyama M: Triggering antiviral response by RIG-I-related RNA helicases. Biochimie, 89: 754-60, 2007.Link

Tasaka M, Sakamoto N, Itakura Y, Nakagawa M, Itsui Y, Sekine-Osajima Y, Nishimura-Sakurai Y, Chen CH, Yoneyama M, Fujita T, Wakita T, Maekawa S, Enomoto N, Watanabe M: Hepatitis C virus non-structural proteins responsible for suppression of the RIG-I/Cardif-induced interferon response. J Gen Virol, 88: 3323-33, 2007.Link

Onoguchi K, Yoneyama M, Takemura A, Akira S, Taniguchi T, Namiki H, Fujita T: Virus infections activate type I and type III interferon genes through a common mechanism. J Biol Chem, 282: 7576-81, 2007.Link

<2006>

Sasai M, Shingai M, Funami K, Yoneyama M, Fujita T, Matsumoto M, Seya, T: NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction. J Immunol, 177: 8676-83, 2006.Link

Yoshikawa T, Iwasaki T, Ida-Hosonuma M, Yoneyama M, Fujita T, Horie H, Miyazawa M, Abe S, Simizu B, Koike S: Role of the alpha/beta interferon response in the acquisition of susceptibility to poliovirus by kidney cells in culture. J Virol, 80: 4313-25, 2006.Link

Kato H, Takeuchi O, Sato S, Yoneyama M, Yamamoto M, Matsui K, Uematsu S, Jung A, Kawai T, Ishii KJ, Yamaguchi O, Otsu K, Tsujimura T, Koh CS, Reis e Sousa C, Matsuura Y, Fujita T, Akira S: Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature, 441: 101-105, 2006.Link

Loo YM, Owen DM, Li K, Erickson AK, Johnson CL, Fish PM, Carney DS, Wang T, Ishida H, Yoneyama M, Fujita T, Saito T, Lee WM, Hagedorn CH, Lau DT, Weinman SA, Lemon SM, Gale M Jr: Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection. Proc Natl Acad Sci USA, 103: 6001-06, 2006.Link

<2005>

Fujita T, Yoneyama M: Innate immune receptors and IRF family transcription factor. Curr Med Chem-Anti-Inflammatory & Anti-Allergy Agents, 4: 29-33, 2005.Link

Kato H, Sato S, Yoneyama M, Yamamoto M, Uematsu S, Matsui K, Tsujimura T, Takeda K, Fujita T, Takeuchi O, Akira S: Cell Type-Specific Involvement of RIG-I in Antiviral Response. Immunity, 23: 19-28, 2005.Link

Yoneyama M, Kikuchi M, Matsumoto K, Imaizumi T, Miyagishi M, Taira K, Foy E, Loo YM, Gale M Jr, Akira S, Yonehara S, Kato A, Fujita T: Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol, 175: 2851-58, 2005.Link

Breiman A, Grandvaux N, Lin R, Ottone C, Akira S, Yoneyama M, Fujita T, Hiscott J, Meurs EF: Inhibition of RIG-I-Dependent Signaling to the Interferon Pathway during Hepatitis C Virus Expression and Restoration of Signaling by IKKe. J Virol, 79: 3969-78, 2005.Link

Ida-Hosonuma M, Iwasaki T, Yoshikawa T, Nagata N, Sato Y, Sata T, Yoneyama M, Fujita T, Taya C, Yonekawa H, Koike S: The Alpha/Beta Interferon Response Controls Tissue Tropism and Pathogenicity of Poliovirus. J Virol, 79: 4460-69, 2005.Link

Foy E, Li K, Sumpter R Jr, Loo YM, Johnson CL, Wang C, Fish PM, Yoneyama M, Fujita T, Lemon SM, Gale M Jr: Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling. Proc Natl Acad Sci USA, 102: 2986-91, 2005.Link

Sumpter R Jr, Loo YM, Foy E, Li K, Yoneyama M, Fujita T, Lemon SM, Gale M Jr: Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I. J Virol, 79: 2689-99, 2005.Link

<2004>

Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T: The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol, 5: 730-737, 2004.Link

Mori M, Yoneyama M, Ito T, Takahashi K, Inagaki F, Fujita T: Identification of Ser-386 of interferon regulatory factor 3 as critical target for inducible phosphorylation that determines activation. J Biol Chem, 279: 9698-702, 2004.Link

<2002>

Suhara W, Yoneyama M, Kitabayashi I, Fujita T: Direct involvement of CREB-binding protein/p300 in sequence-specific DNA binding of virus-activated interferon regulatory factor-3 holocomplex. J Biol Chem, 277: 22304-2231, 2002.Link

Yoneyama M, Suhara W, Fujita T: Control of IRF-3 activation by Phosphorylation. J Interferon Cytokine Res, 22: 73-76, 2002.Link

Shinobu N, Iwamura T, Yoneyama M, Yamaguchi K, Suhara W, Fukuhara Y, Amano F, Fujita T: Involvement of TIRAP/MAL in signaling for the activation of interferon regulatory factor 3 by lipopolysaccharide. FEBS Lett, 517: 251-256, 2002.Link

<2001>

Iwamura T, Yoneyama M, Yamaguchi K, Suhara W, Mori W, Shiota K, Okabe Y, Namiki H, Fujita T: Induction of IRF-3/-7 kinase and NF-kB in response to double-stranded RNA and virus infection: common and unique pathways. Genes Cells, 6: 375-388, 2001.Link

Iwamura T, Yoneyama M, Koizumi N, Okabe Y, Namiki H, Samuel CE, Fujita T: PACT, a double-stranded RNA binding protein acts as a positive regulator for type I interferon gene induced by Newcastle Desease Virus. Biochem Biophys Res Commun, 282: 515-523, 2001.Link

<~2000>

Suhara W, Yoneyama M, Iwamura T, Yoshimura S, Tamura K, Namiki H, Aimoto S, Fujita T: Analysis of virus-induced homomeric and heteromeric protein associations between IRF-3 and coactivator CBP/p300. J Biochem, 128: 301-307, 2000.Link

Yoneyama M, Suhara W, Fukuhara Y, Fukuda M, Nishida E, Fujita T: Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300. EMBO J, 17: 1087-95, 1998.Link

Yoneyama M, Suhara W, Fukuhara Y, Sato M, Ozato K, Fujita T: Autocrine amplification of type I interferon gene expression mediated by interferon stimulated gene factor 3 (ISGF3). J Biochem, 120: 160-190, 1996.Link

Suhara W, Yoneyama M, Yonekawa H, Fujita T: Structure of mouse interferon stimulated gene factor 3g (ISGF3g/p48) cDNA and chromosomal localization of the gene. J Biochem, 119: 231-234, 1996.Link

Shibuya H, Yoneyama M(equal contribution), Ninomiya-Tsuji J, Matsumoto K, Taniguchi T: IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: demonstration of a novel role for c-myc. Cell, 70: 57-67, 1992.Link

Shibuya H, Yoenyama M, Nakamura Y, Harada H, Hatakeyama M, Minamoto S, Kono T, Doi T, White R, Taniguchi T: The human interleukin-2 receptor beta-chain gene: genomic organization, promoter analysis and chromosomal assignment. Nucleic Acids Res, 18: 3697-703, 1990.Link

Shibuya H, Yoneyama M, Taniguchi T: Involvement of a common transcription factor in the regulated expression of IL-2 and IL-2 receptor genes. Int Immunol, 1: 43-49,1989.Link

<2016>

Wittmann A, Lamprinaki D, Bowles KM, Katzenellenbogen E, Knirel YA, Whitfield C, Nishimura T, Matsumoto N, Yamamoto K, Iwakura Y, Saijo S, Kawasaki N: Dectin-2 recognises mannosylated O-antigens of human opportunistic pathogens and augments lipopolysaccharide activation of myeloid cells. J Biol Chem, in press, 2016.Link

Lee MJ, Yoshimoto E, Saijo S, Iwakura Y, Lin X, Katz HR, Kanaoka Y, Barrett NA: hosphoinositide 3-Kinase δ Regulates Dectin-2 Signaling and the Generation of Th2 and Th17 Immunity. J Immunol, 197: 278-87, 2016.Link

Yoshikawa FS, Yabe R, Iwakura Y, de Almeida SR, Saijo S: Dectin-1 and Dectin-2 promote control of the fungal pathogen Trichophyton rubrum independently of IL-17 and adaptive immunity in experimental deep dermatophytosis. Innate Immun, 5: 316-24, 2016.Link

Higashino-Kameda M, Yabe-Wada T, Matsuba S, Takeda K, Anzawa K, Mochizuki T, Makimura K, Saijo S, Iwakura Y, Toga H, Nakamura A: A critical role of Dectin-1 in hypersensitivity pneumonitis. Inflamm Res, 65: 235-44, 2016.Link

Akahori Y, Miyasaka T, Toyama M, Matsumoto I, Miyahara A, Zong T, Ishii K, Kinjo Y, Miyazaki Y, Saijo S, Iwakura Y, Kawakami K: Dectin-2-dependent host defense in mice infected with serotype 3 Streptococcus pneumoniae. BMC Immunol, 17: 1, 2016.Link

<2015>

Murayama MA, Kakuta S, Inoue A, Umeda N, Yonezawa T, Maruhashi T, Tateishi K, Ishigame H, Yabe R, Ikeda S, Seno A, Chi HH, Hashiguchi Y, Kurata R, Tada T, Kubo S, Sato N, Liu Y, Hattori M, Saijo S, Matsushita M, Fujita T, Sumida T, Iwakura Y: CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis. Nat Commun, 6: 8483, 2015.Link

Tang C, Kamiya T, Liu Y, Kadoki M, Kakuta S, Oshima K, Hattori M, Takeshita K, Kanai T, Saijo S, Ohno N, Iwakura Y: Inhibition of Dectin-1 Signaling Ameliorates Colitis by Inducing Lactobacillus-Mediated Regulatory T Cell Expansion in the Intestine. Cell Host Microbe, 18: 183-97, 2015.Link

Akitsu A, Ishigame H, Kakuta S, Chung SH, Ikeda S, Shimizu K, Kubo S, Liu Y, Umemura M, Matsuzaki G, Yoshikai Y, Saijo S, Iwakura Y: IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2(+)Vγ6(+)γδ T cells. Nat Commun, 6: 7464, 2015.Link

Uryu H, Hashimoto D, Kato K, Hayase E, Matsuoka S, Ogasawara R, Takahashi S, Maeda Y, Iwasaki H, Miyamoto T, Saijo S, Iwakura Y, Hill GR, Akashi K, Teshima T: α-Mannan induces Th17-mediated pulmonary graft-versus-host disease in mice. Blood, 125: 3014-23, 2015.Link

Herbst S, Shah A, Mazon Moya M, Marzola V, Jensen B, Reed A, Birrell MA, Saijo S, Mostowy S, Shaunak S, Armstrong-James D: Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus. EMBO Mol Med, 7: 240-58, 2015.Link

Seno A, Maruhashi T, Kaifu T, Yabe R, Fujikado N, Ma G, Ikarashi T, Kakuta S, Iwakura Y: Exacerbation of experimental autoimmune encephalomyelitis in mice deficient for DCIR, an inhibitory C-type lectin receptor. Exp Anim, 64: 109-19, 2015.Link

Maruhashi T, Kaifu T, Yabe R, Seno A, Chung SH, Fujikado N, Iwakura Y: DCIR maintains bone homeostasis by regulating IFN-γ production in T cells. J Immunol, 194: 5681-91, 2015.Link

Yabe R, Shimizu K, Shimizu S, Azechi S, Choi BI, Sudo K, Kubo S, Nakae S, Ishigame H, Kakuta S, Iwakura Y: CCR8 regulates contact hypersensitivity by restricting cutaneous dendritic cell migration to the draining lymph nodes. Int Immunol, 27: 169-81, 2015.Link

<2014>

Nakamura Y, Sato K, Yamamoto H, Matsumura K, Matsumoto I, Nomura T, Miyasaka T, Ishii K, Kanno E, Tachi M, Yamasaki S, Saijo S, Iwakura Y, Kawakami K: Dectin-2 deficiency promotes Th2 response and mucin production in the lungs after pulmonary infection with Cryptococcus neoformans. Infect Immun, 83: 671-81, 2014.Link

Bertuzzi M, Schrettl M, Alcazar-Fuoli L, Cairns TC, Muñoz A, Walker LA, Herbst S, Safari M, Cheverton AM, Chen D, Liu H, Saijo S, Fedorova ND, Armstrong-James D, Munro CA, Read ND, Filler SG, Espeso EA, Nierman WC, Haas H, Bignell EM: The pH-responsive PacC transcription factor of Aspergillus fumigatus governs epithelial entry and tissue invasion during pulmonary aspergillosis. PLoS Pathog, e1004413, 2014.Link

Yonekawa A, Saijo S, Hoshino Y, Miyake Y, Ishikawa E, Suzukawa M, Inoue H, Tanaka M, Yoneyama M, Oh-Hora M, Akashi K, Yamasaki S: Dectin-2 is a direct receptor for mannose-capped lipoarabinomannan of mycobacteria. Immunity, 41: 402-13, 2014.Link

Chiba S, Ikushima H, Ueki H, Yanai H, Kimura Y, Hangai S, Nishio J, Negishi H, Tamura T, Saijo S, Iwakura Y, Taniguchi T: Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses. Elife, e04177, 2014.Link

Norimoto A, Hirose K, Iwata A, Tamachi T, Yokota M, Takahashi K, Saijo S, Iwakura Y, Nakajima H: Dectin-2 promotes house dust mite-induced Th2 and Th17 cell differentiation and allergic airway inflammation in mice. Am J Respir Cell Mol Biol, 51: 201-9, 2014.Link

Öhman T, Teirilä L, Lahesmaa-Korpinen AM, Cypryk W, Veckman V, Saijo S, Wolff H, Hautaniemi S, Nyman TA, Matikainen S. Dectin-1 pathway activates robust autophagy-dependent unconventional protein secretion in human macrophages. J Immunol, 192, 5952-62, 2014.Link

Akitsu A, Kakuta S, Saijo S, Iwakura Y: Rag2-deficient IL-1 Receptor Antagonist-deficient Mice Are a Novel Colitis Model in Which Innate Lymphoid Cell-derived IL-17 Is Involved in the Pathogenesis. Exp Anim, 63: 235-46, 2014.Link

Kobiyama K, Aoshi T, Narita H, Kuroda E, Hayashi M, Tetsutani K, Kyoyama S, Mochizuki S, Sakurai K, Katakai Y, Yasutomi Y, Saijo S, Iwakura Y, Akira S, Coban C, Ishii KJ. Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist. Proc Natl Acad Sci USA, 111, 3086-91, 2014.Link

Parsons MW, Li L, Wallace AM, Lee MJ, Katz HR, Fernandez JM, Saijo S, Iwakura Y, Austen KF, Kanaoka Y, Barrett NA: Dectin-2 regulates the effector phase of house dust mite-elicited pulmonary inflammation independently from its role in sensitization. J Immunol, 192, 1361-71, 2014.Link

Ikeda S, Saijo S, Murayama MA, Shimizu K, Akitsu A, Iwakura Y: Excess IL-1 signaling enhances the development of TH17 cells by downregulating TGF-b-induced Foxp3 Expression. J Immunol, 192, 1361-71, 2014.Link

Wang H, Lebert V, Hung CY, Galles K, Saijo S, Lin X, Cole GT, Klein BS, Wüthrich M: C-type lectin receptors differentialy induce th17 cells and vaccine immunity to the endemic mycosis of north america. J Immunol, 192: 1108-19, 2014.Link

Murayama MA, Kakuta S, Maruhashi T, Shimizu K, Seno A, Kubo S, Sato N, Saijo S, Hattori M, Iwakura Y: CTRP3 plays an important role in the development of collagen-induced arthritis in mice. Biochem Biophys Res Commun, 443, 42-9, 2014.Link

<2013>

Miyasaka T, Akahori Y, Toyama M, Miyamura N, Ishii K, Saijo S, Iwakura Y, Kinjo Y, Miyazaki Y, Oishi K, Kawakami K: Detin-2-dependent NKT cell activation and serotype-specific antibody production in mice immunized with pneumococcal polysaccharide vaccine. PLoS One, 8: e78611, 2013.Link

Ishikawa T, Itoh F, Yoshida S, Saijo S, Matsuzawa T, Gonoi T, Saito T, Okawa Y, Shibata N, Miyamoto T and Yamasaki S: Identification of Distinct ligands for the C-type lectin receptors mincle and dectin-2 in the pathogenic fungus Malassezia. Cell Host & Microbe, 13: 477-488, 2013.Link

<2012>

Ahn J, Gutman D, Saijo S. and Barber GN: STING manifests self DNA-dependent inflammatory disease. Proc Natl Acad Sci USA, 109, 19385-19391, 2012.Link

<2011>

Saijo S. and Iwakura Y: Dectin-1 and Dectin-2 in innate immunity against fungi. Int Immunol, 23, 467-72, 2011.Link

Qi C, Cai Y, Gunn L, Ding C, Li B, Kloecker G, Qian K, Vasilakos J, Saijo S, Iwakura Y, Yannelli JR, Yan J: Differential pathway regulating innate and adaptive antitumor immune responses by particulate and soluble yeast-derived b-glucans. Blood, 117: 6825-36, 2011.Link

Rivera A. Hohl TM, Collins N, Leiner I, Gallegos A, Saijo S, Coward JW, Iwakura Y. Pamer EG: Dectin-1 diversifies Aspergillus fumigatus-specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiation. J Exp Med, 208: 369-81, 2011.Link

Iwakura Y, Ishigame H, Saijo S, Nakae S: Functional specialization of interleukin-17 family members. Immunity, 34: 149-62, 2011.Link

Fei M, Bhatia S, Oriss TB, Yarlagadda M, Khare A, Akira S, Saijo S, Iwakura Y, Fallert Junecko BA, Reinhart TA, Foreman O, Ray P, Kolls J, Ray A: TNF-{alpha} from inflammatory dendritic cells (DCs) regulates lung IL-17A/IL-5 levels and neutrophilia versus eosinophilia during persistent fungal infection. Proc Natl Acad Sci USA, 108: 5360-65, 2011.Link

Drummond RA, Saijo S, Iwakura Y, Brown GD: The role of Syk/CARD9 coupled C-type lectins in antifungal immunity. Eur J Immunol, 41: 276-281, 2011.Link

Bhatia S, Fei M, Yarlagadda M, Qi Z, Akira S, Saijo S, Iwakura Y, van Rooijen N, Gibson GA, St Croix CM, Ray A, Ray P: Rapid host defense against Aspergillus fumigatus involves alveolar macrophages with a predominance of alternatively activated phenotype. PLoS One, 6: e15943, 2011.Link

<2010>

Xiao G, Miyazato A, Abe Y, Zhang T, Nakamura K, Inden K, Tanaka M, Tanno D, Miyasaka T, Ishii K, Takeda K, Akira S, Saijo S, Iwakura Y, Adachi Y, Ohno N, Yamamoto N, Kunishima H, Hirakata Y, Kaku M, Kawakami K: Activation of myeloid dendritic cells by deoxynucleic acids from Cordyceps sinensis via a Toll-like receptor 9-dependent pathway. Cell Immunol, 263: 241-250, 2010.Link

Saijo S, Ikeda S, Yamabe K, Kakuta S, Ishigame H, Akitsu A, Fujikado N, Kusaka T, Kubo S, Chung SH, Komatsu R, Miura N, Adachi Y, Ohno N, Shibuya K, Yamamoto N, Kawakami K, Yamasaki S, Saito T, Akira S, Iwakura Y: Dectin-2 Recognition of α-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicans. Immunity, 32: 681-691, 2010.Link

Ritter M, Gross O, Kays S, Ruland J, Nimmerjahn F, Saijo S, Tschopp J, Layland LE, Prazeres da Costa C: Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses. Proc Natl Acad Sci USA, 107: 20459-464, 2010.Link

Nakajima A, Matsuki T, Komine M, Asahina A, Horai R, Nakae S, Ishigame H, Kakuta S, Saijo S, Iwakura Y: TNF, but Not IL-6 and IL-17, Is Crucial for the Development of T Cell-Independent Psoriasis-Like Dermatitis in Il1rn^-/- Mice. J Immunol, 185: 1887-93, 2010.Link

Echeverry A, Saijo S, Schesser K, Adkins B: Yersinia enterocolitica Promotes Robust Mucosal Inflammatory T-Cell Immunity in Murine Neonates. Infect Immun, 78: 3595-608, 2010.Link

Chung SH, Seki K, Choi BI, Kimura KB, Ito A, Fujikado N, Saijo S, Iwakura Y: CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen-induced arthritis. Arthritis Res Ther, 12: R188, 2010.Link

<2009>

Miyazato A, Nakamura K, Yamamoto N, Mora-Montes HM, Tanaka M, Abe Y, Tanno D, Inden K, Gang X, Ishii K, Takeda K, Akira S, Saijo S, Iwakura Y, Adachi Y, Ohno N, Mitsutake K, Gow NAR, Kaku M, Kawakami K: Toll-Like Receptor 9-Dependent Activation of Myeloid Dendritic Cells by Deoxynucleic Acids from Candida albicans. Infect Immun, 77: 3056-64, 2009.Link

<2008>

Nakamura K, Miyazato A, Xiao G, Hatta M, Inden K, Aoyagi T, Shiratori K, Takeda K, Akira S, Saijo S, Iwakura Y, Adachi Y, Ohno N, Suzuki K, Fujita J, Kaku M, Kawakami K: Deoxynucleic acids from Cryptococcus neoformans activate myeloid dendritic cells via a TLR9-dependent pathway. J Immunol, 180: 4067-74, 2008.Link

Nakamura K, Miyazato A, Koguchi Y, Adachi Y, Ohno N, Saijo S, Iwakura Y, Takeda K, Akira S, Fujita J, Ishii K, Kaku M, Kawakami K: Toll-like receptor 2 (TLR2) and dectin-1 contribute to the production of IL-12p40 by bone marrow-derived dendritic cells infected with Penicillium marneffei. Microbes Infect, 10, 1223-27, 2008.Link

Iwakura Y, Nakae S, Saijo S, Ishigame H: The roles of IL-17A in inflammatory immune responses and host defense against pathogens. Immunol Rev, 226: 57-79, 2008.Link

Fujikado N, Saijo S, Yonezawa T, Shimamori K, Ishii A, Sugai S, Kotaki H, Sudo K, Nose M, Iwakura Y: Dcir deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells. Nat Med, 14: 176-180, 2008.Link

<2007>

Venkataraman T, Valdes M, Elsby R, Kakuta S, Caceres G, Saijo S, Iwakura Y, Barber GN: Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses. J Immunol, 178: 6444-55, 2007.Link

Nakamura K, Kinjo T, Saijo S, Miyazato A, Adachi Y, Ohno N, Fujita J, Kaku M, Iwakura Y, Kawakami K: Dectin-1 is not required for the host defense to Cryptococcus neoformans. Microbiol Immunol, 51: 1115-9, 2007.Link

Hara H, Ishihara C, Takeuchi A, Imanishi T, Xue L, Morris SW, Inui M, Takai T, Shibuya A, Saijo S, Iwakura Y, Ohno N, Koseki H, Yoshida H, Penninger JM, Saito T: The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors. Nat Immunol, 8: 619-629, 2007.Link

Saijo S, Fujikado N, Furuta T, Chung SH, Kotaki H, Seki K, Sudo K, Akira S, Adachi Y, Ohno N, Kinjo T, Nakamura K, Kawakami K, Iwakura Y: Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans. Nat Immunol, 8: 39-46, 2007.Link

<2006>

Ishigame H, Nakajima A, Saijo S, Komiyama Y, Nambu A, Matsuki T, Nakae S, Horai R, Kakuta S, Iwakura Y: The role of TNFalpha and IL-17 in the development of excess IL-1 signaling-induced inflammatory diseases in IL-1 receptor antagonist-deficient mice. Ernst Schering Res Found Workshop, 56: 129-53, 2006.Link

Fujikado N, Saijo S, Iwakura Y: Identification of arthritis-related gene clusters by microarray analysis of two independent mouse models for rheumatoid arthritis. Arthritis Res Ther, 8: R100, 2006.Link

<2004>

Horai R, Nakajima A, Habiro K, Kotani M, Nakae S, Matsuki T, Nambu A, Saijo S, Kotaki H, Sudo K, Okahara A, Tanioka H, Ikuse T, Ishii N, Schwartzberg PL, Abe R, Iwakura Y: TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice. J Clin Invest, 114: 1603-11, 2004.Link

<2003>

Nakae S, Saijo S, Horai R, Sudo K, Mori S, Iwakura Y: IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist. Proc Natl Acad Sci USA, 100: 5986-90, 2003.Link

Ono Y, Ogihara Y, Saijo S, Iwakura Y, Inoue M: Evaluation of Kampo medicines used to treat rheumatoid arthritis in collagen-induced arthritic and pX transgenic mice. Mod Rheumatol, 13: 50-56, 2003.Link

<2002>

Saijo S, Asano M, Horai R, Yamamoto H, Iwakura Y: Suppression of autoimmune arthritis in interleukin-1-deficient mice in which T cell activation is impaired due to low levels of CD40 ligand and OX40 expression on T cells. Arthritis Rheum, 46: 533-544, 2002.Link

<~2000>

Tanaka J, Ozaki H, Yasuda J, Horai R, Tagawa Y, Asano M, Saijo S, Imai M, Sekikawa K, Kopf M, Iwakura Y: Lipopolysaccharide-induced HIV-1 expression in transgenic mice is mediated by tumor necrosis factor-alpha and interleukin-1, but not by interferon-gamma nor interleukin-6. AIDS, 14: 1299-307, 2000.Link

Horai R, Saijo S, Tanioka H, Nakae S, Sudo K, Okahara A, Ikuse T, Asano M, Iwakura Y: Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice. J Exp Med, 191: 313-20, 2000.Link

Saijo S, Kotani M, Habu K, Ishitsuka C, Yamamoto H, Sekiguchi T, Iwakura Y: Bone marrow-derived cells are responsible for the development of autoimmune arthritis in human T cell leukemia virus type I-transgenic mice and those of normal mice can suppress the disease. J Immunol, 163: 5700-7, 1999.Link

Habu K, Nakayama-Yamada J, Asano M, Saijo S, Itagaki K, Horai R, Yamamoto H, Sekiguchi T, Nosaka T, Hatanaka M, Iwakura Y: The human T cell leukemia virus type I-tax gene is responsible for the development of both inflammatory polyarthropathy resembling rheumatoid arthritis and noninflammatory ankylotic arthropathy in transgenic mice. J Immunol, 162: 2956-63, 1999.Link

Iwakura Y, Itagaki K, Ishitsuka C, Yamasaki Y, Matsuzawa A, Yonehara S, Karasawa S, Ueda S, Saijo S: The development of autoimmune inflammatory arthropathy in mice transgenic for the human T cell leukemia virus type-1 env-pX region is not dependent on H-2 haplotypes and modified by the expression levels of Fas antigen. J Immunol, 161: 6592-8, 1998.Link

Iwakura Y, Tosu M, Yoshida E, Saijo S, Nakayama-Yamada J, Itagaki K, Asano M, Siomi H, Hatanaka M, Takeda T et al.: Augmentation of c-fos and c-jun expression in transgenic mice carrying the human T-cell leukemia virus type-I tax gene. Virus Genes, 9: 161-70, 1995.Link

Iwakura Y, Saijo S, Kioka Y, Nakayama-Yamada J, Itagaki K, Tosu M, Asano M, Kanai Y, Kakimoto K: Autoimmunity induction by human T cell leukemia virus type 1 in transgenic mice that develop chronic inflammatory arthropathy resembling rheumatoid arthritis in humans. J Immunol, 155: 1588-98, 1995.Link

Yamamoto H, Sekiguchi T, Itagaki K, Saijo S, Iwakura Y: Inflammatory polyarthritis in mice transgenic for human T cell leukemia virus type I. Arthritis Rheum, 36: 1612-20, 1993.Link