矢部力朗

専門分野

免疫学、糖鎖生物学、実験動物学

研究テーマ

1. 真菌感染に対する免疫応答制御機構の解明
2. 自己免疫疾患・アレルギー発症のメカニズム解明

所属学協会

日本免疫学会、日本実験動物学会

主な発表論文、著書

1. Yabe R, Saijo S. Dectin-2 in Antimicrobial Immunity and Homeostasis C-Type Lectin Receptors in Immunity. 3-13, 2016.
2. Yoshikawa FS, Yabe R, Iwakura Y, de Almeida SR, Saijo S. Dectin-1 and Dectin-2 promote control of the fungal pathogen Trichophyton rubrum independently of IL-17 and adaptive immunity in experimental deep dermatophytosis. Innate Immun; 22(5): 316-24, 2016.
3. Murayama MA, Kakuta S, Inoue A, Umeda N, Yonezawa T, Maruhashi T, Tateishi K, Ishigame H, Yabe R, Ikeda S, Seno A, Chi HH, Hashiguchi Y, Kurata R, Tada T, Kubo S, Sato N, Liu Y, Hattori M, Saijo S, Matsushita M, Fujita T, Sumida T, Iwakura Y. CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis. Nat Commun. 6:8483, 2015.
4. Maruhashi T, Kaifu T, Yabe R, Seno A, Chung SH, Fujikado N, and Iwakura Y. DCIR Maintains Bone Homeostasis by Regulating IFN-γ Production in T cells. J Immunol 194, 5681-5691, 2015.
5. Seno A, Maruhashi T, Kaifu T, Yabe R, Fujikado N, Ma G, Ikarashi T, Kakuta S, and Iwakura Y. Exacerbation of experimental autoimmune encephalomyelitis in mice deficient for DCIR, an inhibitory C-type lectin receptor. Exp Anim 64, 109-119, 2015.
6. Yabe R, Shimizu K, Shimizu S, Azechi S, Choi BI, Sudo K, Kubo S, Nakae S, Ishigame H, Kakuta S, and Iwakura Y. CCR8 regulates contact hypersensitivity by restricting cutaneous dendritic cell migration to the draining lymph nodes. Int Immunol 27, 169-181, 2015.
7. Yabe R, Iwakura Y, Saijo, S. C-Type Lectin Receptors in Host Defense against Microbial Pathogens. Glycoscinece: Biology and Medicine, 1319-1329, 2015.
8. Hu D, Tateno H, Kuno A, Yabe R, and Hirabayashi J. Directed evolution of lectins with sugar-binding specificity for 6-sulfo-galactose. J Biol Chem 287, 20313-20320, 2012.
9. Tateno H, Yabe R, Sato T, Shibazaki A, Shikanai T, Gonoi T, Narimatsu H, and Hirabayashi J. Human ZG16p recognizes pathogenic fungi through non-self polyvalent mannose in the digestive system. Glycobiology. 22, 210-220, 2012.
10. Chen Y, Hu D, Yabe R, Tateno H, Qin SY, Matsumoto N, Hirabayashi J, and Yamamoto K. Role of malectin in Glc2Man9GlcNAc2-dependent quality control of α1-antitrypsin. Mol Biol Cell 22, 3559-3570, 2011.
11. Imamura K, Takeuchi H, Yabe R, Tateno H, and Hirabayashi J. Engineering of the glycan-binding specificity of Agrocybe cylindracea galectin towards α(2,3)-linked sialic acid by saturation mutagenesis. J Biochem 150, 545-552, 2011.
12. Yabe R, Tateno H, and Hirabayashi J. Frontal affinity chromatography analysis of constructs of DC-SIGN, DC-SIGNR and LSECtin extend evidence for affinity to agalactosylated N-glycans. FEBS J 277, 4010-4026, 2010.

研究

• 研究分野・プロジェクト研究
• 研究者リスト