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Rikio Yabe

Position Assistant Professor
Research Projects Project for Cytokine Research
Division Division of Molecular Immunology
TEL +81 43 226 2796
FAX +81 43 226 2791
E-mail rikio-yabe[at]


Immunology, Glycobiology, Laboratory Animal Science

Main topics of research

  1. Host immune responses against fungal infection
  2. Autoimmune disease and allergy

Main publications

  1. Yabe R, Saijo S. Dectin-2 in Antimicrobial Immunity and Homeostasis C-Type Lectin Receptors in Immunity. 3-13, 2016.
  2. Yoshikawa FS, Yabe R, Iwakura Y, de Almeida SR, Saijo S. Dectin-1 and Dectin-2 promote control of the fungal pathogen Trichophyton rubrum independently of IL-17 and adaptive immunity in experimental deep dermatophytosis. Innate Immun; 22(5): 316-24, 2016.
  3. Murayama MA, Kakuta S, Inoue A, Umeda N, Yonezawa T, Maruhashi T, Tateishi K, Ishigame H, Yabe R, Ikeda S, Seno A, Chi HH, Hashiguchi Y, Kurata R, Tada T, Kubo S, Sato N, Liu Y, Hattori M, Saijo S, Matsushita M, Fujita T, Sumida T, Iwakura Y. CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis. Nat Commun. 6:8483, 2015.
  4. Maruhashi T, Kaifu T, Yabe R, Seno A, Chung SH, Fujikado N, and Iwakura Y. DCIR Maintains Bone Homeostasis by Regulating IFN-γ Production in T cells. J Immunol 194, 5681-5691, 2015.
  5. Seno A, Maruhashi T, Kaifu T, Yabe R, Fujikado N, Ma G, Ikarashi T, Kakuta S, and Iwakura Y. Exacerbation of experimental autoimmune encephalomyelitis in mice deficient for DCIR, an inhibitory C-type lectin receptor. Exp Anim 64, 109-119, 2015.
  6. Yabe R, Shimizu K, Shimizu S, Azechi S, Choi BI, Sudo K, Kubo S, Nakae S, Ishigame H, Kakuta S, and Iwakura Y. CCR8 regulates contact hypersensitivity by restricting cutaneous dendritic cell migration to the draining lymph nodes. Int Immunol 27, 169-181, 2015.
  7. Yabe R, Iwakura Y, Saijo, S. C-Type Lectin Receptors in Host Defense against Microbial Pathogens. Glycoscinece: Biology and Medicine, 1319-1329, 2015.
  8. Hu D, Tateno H, Kuno A, Yabe R, and Hirabayashi J. Directed evolution of lectins with sugar-binding specificity for 6-sulfo-galactose. J Biol Chem 287, 20313-20320, 2012.
  9. Tateno H, Yabe R, Sato T, Shibazaki A, Shikanai T, Gonoi T, Narimatsu H, and Hirabayashi J. Human ZG16p recognizes pathogenic fungi through non-self polyvalent mannose in the digestive system. Glycobiology. 22, 210-220, 2012.
  10. Chen Y, Hu D, Yabe R, Tateno H, Qin SY, Matsumoto N, Hirabayashi J, and Yamamoto K. Role of malectin in Glc2Man9GlcNAc2-dependent quality control of α1-antitrypsin. Mol Biol Cell 22, 3559-3570, 2011.
  11. Imamura K, Takeuchi H, Yabe R, Tateno H, and Hirabayashi J. Engineering of the glycan-binding specificity of Agrocybe cylindracea galectin towards α(2,3)-linked sialic acid by saturation mutagenesis. J Biochem 150, 545-552, 2011.
  12. Yabe R, Tateno H, and Hirabayashi J. Frontal affinity chromatography analysis of constructs of DC-SIGN, DC-SIGNR and LSECtin extend evidence for affinity to agalactosylated N-glycans. FEBS J 277, 4010-4026, 2010.